Difference between revisions of "YGR014W"
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==Community Commentary== | ==Community Commentary== | ||
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| + | == Transmembrane Domain GxxxG == | ||
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| + | The transmembrane domain of Msb2 shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiGlviGvvvG. The presence of multiple, overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Msb2 dimerises. | ||
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=== Protein Details === | === Protein Details === | ||
Revision as of 08:27, 21 March 2013
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| Systematic name | YGR014W |
| Gene name | MSB2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:516943..520863 |
| Primary SGDID | S000003246 |
Description of YGR014W: Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate[1][2][3][4]
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Contents
Community Commentary
Transmembrane Domain GxxxG
The transmembrane domain of Msb2 shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiGlviGvvvG. The presence of multiple, overlapping GxxxG motifs [5] strongly indicates that Msb2 dimerises.
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [6]
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References
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- ↑ Bender A and Pringle JR (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80 SGD PMID 2690082
- ↑ Cullen PJ, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708 SGD PMID 15256499
- ↑ O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 SGD PMID 12052881
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
- ↑ submitted by Jeff Ubersax on 2004-01-27
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