Difference between revisions of "YDR103W"
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| − | '''Description of YDR103W:''' Pheromone- | + | '''Description of YDR103W:''' Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation<ref name='S000048143'>Choi KY, et al. (1999) Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68 {{SGDpaper|S000048143}} PMID 10233162</ref><ref name='S000120550'>Garrenton LS, et al. (2006) Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev 20(14):1946-58 {{SGDpaper|S000120550}} PMID 16847350</ref><ref name='S000129764'>Good M, et al. (2009) The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 136(6):1085-97 {{SGDpaper|S000129764}} PMID 19303851</ref><ref name='S000126703'>Hao N, et al. (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell 30(5):649-56 {{SGDpaper|S000126703}} PMID 18538663</ref><ref name='S000053549'>Kranz JE, et al. (1994) The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev 8(3):313-27 {{SGDpaper|S000053549}} PMID 8314085</ref><ref name='S000133845'>Malleshaiah MK, et al. (2010) The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature 465(7294):101-5 {{SGDpaper|S000133845}} PMID 20400943</ref><ref name='S000050302'>Printen JA and Sprague GF Jr (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138(3):609-19 {{SGDpaper|S000050302}} PMID 7851759</ref><ref name='S000086905'>Winters MJ, et al. (2005) A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol Cell 20(1):21-32 {{SGDpaper|S000086905}} PMID 16209942</ref><ref name='S000150544'>Zalatan JG, et al. (2012) Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation. Science () |
| − | {{SGDpaper| | + | {{SGDpaper|S000150544}} PMID 22878499</ref> |
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Latest revision as of 13:05, 28 August 2012
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| Systematic name | YDR103W |
| Gene name | STE5 |
| Aliases | HMD3, NUL3 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:658350..661103 |
| Primary SGDID | S000002510 |
Description of YDR103W: Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation[1][2][3][4][5][6][7][8][9]
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References
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- ↑ Choi KY, et al. (1999) Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68 SGD PMID 10233162
- ↑ Garrenton LS, et al. (2006) Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev 20(14):1946-58 SGD PMID 16847350
- ↑ Good M, et al. (2009) The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 136(6):1085-97 SGD PMID 19303851
- ↑ Hao N, et al. (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell 30(5):649-56 SGD PMID 18538663
- ↑ Kranz JE, et al. (1994) The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev 8(3):313-27 SGD PMID 8314085
- ↑ Malleshaiah MK, et al. (2010) The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature 465(7294):101-5 SGD PMID 20400943
- ↑ Printen JA and Sprague GF Jr (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138(3):609-19 SGD PMID 7851759
- ↑ Winters MJ, et al. (2005) A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol Cell 20(1):21-32 SGD PMID 16209942
- ↑ Zalatan JG, et al. (2012) Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation. Science () SGD PMID 22878499
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