Difference between revisions of "YER174C"
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| − | '''Description of YER174C:''' Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance<ref name='S000048888'>Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 {{SGDpaper|S000048888}} PMID 10567543</ref><ref name='S000136872'>Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 | + | '''Description of YER174C:''' Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5<ref name='S000149549'>Pimentel C, et al. (2012) The role of the yap5 transcription factor in remodeling gene expression in response to fe bioavailability. PLoS One 7(5):e37434 {{SGDpaper|S000149549}} PMID 22616008</ref><ref name='S000048888'>Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 {{SGDpaper|S000048888}} PMID 10567543</ref><ref name='S000136872'>Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 |
{{SGDpaper|S000136872}} PMID 20850176</ref> | {{SGDpaper|S000136872}} PMID 20850176</ref> | ||
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Latest revision as of 13:05, 20 June 2012
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| Systematic name | YER174C |
| Gene name | GRX4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:539168..538434 |
| Primary SGDID | S000000976 |
Description of YER174C: Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5[1][2][3]
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References
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- ↑ Pimentel C, et al. (2012) The role of the yap5 transcription factor in remodeling gene expression in response to fe bioavailability. PLoS One 7(5):e37434 SGD PMID 22616008
- ↑ Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 SGD PMID 10567543
- ↑ Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 SGD PMID 20850176
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