Difference between revisions of "YOR211C"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| Line 47: | Line 47: | ||
{{ShortCenteredHR}} | {{ShortCenteredHR}} | ||
| + | |||
| + | |||
| + | |||
| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
| + | <!-- | ||
| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
| + | --> | ||
<protect> | <protect> | ||
Revision as of 12:02, 21 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YOR211C |
| Gene name | MGM1 |
| Aliases | MNA1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:741570..738925 |
Description of YOR211C: Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy[1][2][3][4]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Protein Details
Mature Length (direct evidence)
Protein length: 822 aa The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). [5] [6]
Protein Function/Process
Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. [5] [6]
Protein Localization
Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. [5] [6]
<protect>
References
See Help:References on how to add references
- ↑ Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460
- ↑ Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 SGD PMID 12808034
- ↑ Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 SGD PMID 12123827
- ↑ Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 SGD PMID 15125685
- ↑ 5.0 5.1 5.2 Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 SGD PMID 12707284
- ↑ 6.0 6.1 6.2 submitted by Andreas Reichert on 2003-09-25
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
