Difference between revisions of "YLR318W"
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 12:02, 21 February 2007
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| Systematic name | YLR318W |
| Gene name | EST2 |
| Aliases | TERT |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:766542..769196 |
Description of YLR318W: Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia[1][2][3]
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References
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- ↑ Yamaguchi H, et al. (2005) Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352(14):1413-24 SGD PMID 15814878
- ↑ Livengood AJ, et al. (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74 SGD PMID 11884619
- ↑ Lingner J, et al. (1997) Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A 94(21):11190-5 SGD PMID 9326584
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