Difference between revisions of "YMR247C"
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| − | '''Description of YMR247C:''' RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse | + | '''Description of YMR247C:''' RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice<ref name='S000136433'>Bengtson MH and Joazeiro CA (2010) Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467(7314):470-3 {{SGDpaper|S000136433}} PMID 20835226</ref><ref name='S000120715'>Braun MA, et al. (2007) Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol Cell Biol 27(8):2800-11 {{SGDpaper|S000120715}} PMID 17283062</ref><ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 |
{{SGDpaper|S000115662}} PMID 16702403</ref> | {{SGDpaper|S000115662}} PMID 16702403</ref> | ||
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Revision as of 13:05, 12 May 2011
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| Systematic name | YMR247C |
| Gene name | RKR1 |
| Aliases | LTN1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:768039..763351 |
| Primary SGDID | S000004861 |
Description of YMR247C: RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice[1][2][3]
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References
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- ↑ Bengtson MH and Joazeiro CA (2010) Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467(7314):470-3 SGD PMID 20835226
- ↑ Braun MA, et al. (2007) Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol Cell Biol 27(8):2800-11 SGD PMID 17283062
- ↑ Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 SGD PMID 16702403
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