Difference between revisions of "YDR118W"
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| − | '''Description of YDR118W:''' Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition<ref name='S000058476'>Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 {{SGDpaper|S000058476}} PMID 10465783</ref><ref name='S000044570'>Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 | + | '''Description of YDR118W:''' Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis<ref name='S000142171'>Buschhorn BA, et al. (2011) Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol 18(1):6-13 {{SGDpaper|S000142171}} PMID 21186364</ref><ref name='S000058476'>Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 {{SGDpaper|S000058476}} PMID 10465783</ref><ref name='S000044570'>Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
{{SGDpaper|S000044570}} PMID 9469814</ref> | {{SGDpaper|S000044570}} PMID 9469814</ref> | ||
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Revision as of 13:05, 6 June 2011
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| Systematic name | YDR118W |
| Gene name | APC4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:685882..687840 |
| Primary SGDID | S000002525 |
Description of YDR118W: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis[1][2][3]
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References
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- ↑ Buschhorn BA, et al. (2011) Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol 18(1):6-13 SGD PMID 21186364
- ↑ Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 SGD PMID 10465783
- ↑ Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 SGD PMID 9469814
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