Difference between revisions of "YIL049W"
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− | '''Description of YIL049W:''' | + | '''Description of YIL049W:''' Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation)<ref name='S000135785'>Cantagrel V, et al. (2010) SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142(2):203-17 {{SGDpaper|S000135785}} PMID 20637498</ref><ref name='S000042772'>Mosch HU and Fink GR (1997) Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145(3):671-84 |
{{SGDpaper|S000042772}} PMID 9055077</ref> | {{SGDpaper|S000042772}} PMID 9055077</ref> | ||
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Revision as of 14:05, 22 March 2011
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Systematic name | YIL049W |
Gene name | DFG10 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr IX:260158..260919 |
Primary SGDID | S000001311 |
Description of YIL049W: Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation)[1][2]
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References
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- ↑ Cantagrel V, et al. (2010) SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142(2):203-17 SGD PMID 20637498
- ↑ Mosch HU and Fink GR (1997) Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145(3):671-84 SGD PMID 9055077
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