Difference between revisions of "YBR170C"
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| − | '''Description of YBR170C:''' | + | '''Description of YBR170C:''' Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD)<ref name='S000071485'>Bays NW and Hampton RY (2002) Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Curr Biol 12(10):R366-71 {{SGDpaper|S000071485}} PMID 12015140</ref><ref name='S000069870'>Bays NW, et al. (2001) HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell 12(12):4114-28 {{SGDpaper|S000069870}} PMID 11739805</ref><ref name='S000140158'>Heo JM, et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80 {{SGDpaper|S000140158}} PMID 21070972</ref><ref name='S000066133'>Hitchcock AL, et al. (2001) The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell 12(10):3226-41 |
{{SGDpaper|S000066133}} PMID 11598205</ref> | {{SGDpaper|S000066133}} PMID 11598205</ref> | ||
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Revision as of 13:05, 15 February 2011
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| Systematic name | YBR170C |
| Gene name | NPL4 |
| Aliases | HRD4 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:578086..576344 |
| Primary SGDID | S000000374 |
Description of YBR170C: Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD)[1][2][3][4]
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Contents
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References
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- ↑ Bays NW and Hampton RY (2002) Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Curr Biol 12(10):R366-71 SGD PMID 12015140
- ↑ Bays NW, et al. (2001) HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell 12(12):4114-28 SGD PMID 11739805
- ↑ Heo JM, et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80 SGD PMID 21070972
- ↑ Hitchcock AL, et al. (2001) The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell 12(10):3226-41 SGD PMID 11598205
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