Positions in yeast labs

Multiple Postdoctoral Positions: University of Toronto / Harvard Medical School collaboration

Multiple postdoctoral positions are available within a collaboration led by faculty at either the Terrence Donnelly Centre for Cellular and Biomolecular Research or the Samuel Lunenfeld Research Institute together with Dr. Frederick Roth (Harvard Medical School, Dept of Biological Chemistry and Molecular Biology). Positions are in Toronto, ON but are collaborative and may initially require travel to Harvard Medical School in Boston, MA.

Postdoctoral Fellow – Pathway Genomics. Applicants should have substantial experience in molecular genetics and strong intellectual interest in systematic genetic approaches to characterize gene function, pathway order and drug mechanism. Potential projects include: 1) systematic measurement of synergistic drug combinations in human cell lines; 2) development of a deep sequencing approach for measuring genetic interactions; and 3) using deep sequencing to efficiently screen for kinase-dependent protein interactions.

Postdoctoral Fellow – Synthetic Biology. Applicants should have substantial experience in molecular genetics, and strong intellectual interest in the use of synthetic biology and genetic analysis to characterize gene function, pathway order, and drug mechanism. Potential projects include: a strategy for rapid production of strains in which many genes have been precisely re-engineered, in order to study multigenic genetic interactions and reconstruct pathways from human and other genetically recalcitrant systems; implementation of a physical genetic algorithm to optimize reconstructed or synthetic pathways. Potential applications include the study of drug resistance and metabolism or development of synthetic tools for large-scale genetic perturbation analysis.

Postdoctoral Fellow – Computational Genomics. Seeking a creative and talented postdoctoral fellow interested in using causal reasoning to reveal cellular pathways and drug mechanism of action via integration and analysis of large-scale genomic and proteomic experiments. Involves large-scale data from ongoing collaborations on protein interaction mapping, high-content cellular and organismal phenotyping, protein expression and metabolite profiling, and discovery of genetic interactions to identify and characterize biological pathways. Qualifications are a track record of imaginative quantitative research and a solid foundation in a substantial subset of computer science, mathematics, statistics, genetics and molecular biology.

To apply for any of these positions, please submit a curriculum vitae and contact information for three references to fritz_roth@hms.harvard.edu. http://llama.med.harvard.edu/positions.html

(posted April 23, 2010)

Postdoctoral Position in Cell Biology (Yeast) : IGBMC, Strasbourg, France

A postdoctoral position is open in Strasbourg (France) at the European Center, Institute of Genetics and Molecular and Cellular Biology (IGBMC): the project will focus on the dynamics of the cytokinetic ring in the fission yeast S. pombe. The roles of the GTPase Rho, actin polymerisation, and myosin will be studied. The work will involve genetics, cell biology, microscopy, microfabrication and microfluidics; for more information, send a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

PhD and Postdoctoral positions, Institute of Environmental Sciences at the Jagiellonian University, Kraków, Poland

“-Molecular mechanisms of genetic and environmental interactions for fitness in the budding yeast S. cerevisiae” in the laboratory of professor Ryszard Korona

Institute of Environmental Sciences at the Jagiellonian University is opening applications for: 4-year interdisciplinary doctoral studies programme in ecology in English, with net-scholarships 2200 PLN per month, offering research in Poland and half- year placements in academic centres outside Poland and a choice of 4 out of 8 courses from different scientific disciplines conducted by eminent Polish and foreign specialists Application deadline: 10 June 2010

20-month fellowship programme for strongly motivated scientists with a PhD degree in Biology, Ecology or related field, with net- fellowship 3200 PLN per month plus social benefits, realised in one of the research groups at the Institute of Environmental Sciences and a monthly internship at universities in Europe and the U.S. Application deadline: 30 April 2010

Detailed information, containing the list of all research topics proposed for PhD students, profile of the applicant and application instructions is available at http://www.eko.uj.edu.pl/ecology/.

Project co-financed by the European Union under the European Social Fund

Postdoctoral research position, Harvard University

Postdoctoral research position is available for a scientist to investigate host-pathogen interactions using C. elegans (J Exp Med 2009, 206:637-53; PNAS 2008,105:14585-90; PLoS Pathog. 2007, 3:e101 and e18; Eukaryot Cell 2009;8:732-7). Please send letter of application, curriculum vitae, statement of research interests, and have 3 current letters of professional reference emailed to Dr. E. Mylonakis emylonakis[AT]partners.org. (posted September 2, 2009)

MGH is an AA/EEO employer.

http://www2.massgeneral.org/id/labs/mylonakis

http://chemicalbiology.mgh.harvard.edu/labs-mylonakis.htm

Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge

Postdoctoral Research Associate in the group of Dr Janneke Balk, Department of Plant Sciences, University of Cambridge

Salary: £27,183-£35,469 pa Limit of tenure: grant funding is available for 3 years in the first instance. Start date: 1 January 2010

Applicants must have a PhD, and a background in fungal genetics will be highly preferred. Previous experience in molecular biology and biochemistry methods is essential. This project is funded by the Wellcome Trust and includes part-time technical assistance.

The assembly of iron-sulphur cofactors in respiratory complex I

Complex I deficiencies are the most common cause of respiratory chain dysfunction, but how this largest of the respiratory complexes is assembled, including its unique chain of eight iron-sulphur (Fe-S) clusters, is poorly understood. This project aims to investigate the assembly of complex I using the yeast Yarrowia lipolytica as a genetic model organism, and will focus on: 1) Further analysis of the molecular role of Ind1, a recently identified Fe-S scaffold protein important for complex I assembly in Yarrowia and human cell lines (Bych et al 2008; Sheftel et al, unpublished). 2) Development of Yarrowia yeast as a genetic model organism to perform forward genetics screens, complemented by a biochemical approach, to identify additional complex I assembly factors, in particular those that assist Ind1 with Fe-S cluster insertion. 3) Translation of the findings to human disease: identification of human orthologues and whether they are implicated in complex I disorders.

This project involves collaborations with Dr Judy Hirst at the MRC Cambridge (in vitro cluster assembly in complex I subunits), Professor Ulrich Brandt, Frankfurt (complex I function and genetics in Yarrowia yeast) and Professor Jan Smeitink, Nijmegen (translation of the findings to human respiratory disease).

Dr Janneke Balk started an independent research group in 2005, focussing on Fe-S protein biogenesis in (higher) eukaryotes. Her dynamic and international group is rapidly expanding and moving to new laboratory space this autumn.

The University of Cambridge is a world-class research institute, which is particulary strong in biomedical sciences.

Reference: Bych K, Kerscher S, Netz DJA, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U and Balk, J (2008). The iron-sulfur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736-46.

For further enqueries: Janneke Balk, jb511@cam.ac.uk To apply, see http://www.plantsci.cam.ac.uk/jobs/content.html

Postdoctoral Position at University of Texas Health Science Center at San Antonio

A postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine morphology and virulence of Candida albicans, the major fungal pathogen, in response to host environmental cues (for additional details see Carlisle, et al., PNAS 106:599-604 (2009)[1], Banerjee et al., MBC 19:1354-1365 (2008)[2] and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis.

Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis, as well as S. cerevisiae researchers interested in transitioning to fungal pathogenesis, are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu).

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

Postdoctoral or Staff Scientist Position at Purdue University

Postdoctoral/Staff scientist position available in yeast functional genomics of chromosome segregation at Purdue University. Project goals are to define, on a global scale, the effect of phosphorylation by the Aurora kinase on protein interactions controlling chromosome segregation process in yeast. Project is funded for up to five years by NIH and will involve high-throughput screening and lab automation, genome-wide studies, microscopy, yeast molecular biology and bioinformatic analysis. Applicants should have a recent PhD in any field of biology that includes a strong conceptual and experimental background in Genetics, and/or Molecular and Cell Biology.

Applicants should send a CV by email to Dr. Tony Hazbun listed at the following web site: http://www.mcmp.purdue.edu/faculty/?uid=hazbun

Postdoctoral Position at Rutgers University

A postdoctoral position is available at the Biotech Center at Rutgers University in the laboratory of Dr. Nilgun E. Tumer to investigate the mechanisms of uptake, transport and cytotoxicity of ricin and Shiga-like toxins. The Tumer lab works on elucidating the basic mechanisms of action of ricin and Shiga-like toxins using Saccharomyces cerevisae and C. elegans as model systems. Both toxins depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. Our goal is to identify the targets of these toxins to understand the mechanism by which they kill cells and to develop therapeutic intervention strategies. The successful candidate will use genetic, cell biology and chemical genomic approaches to investigate the mechanism of uptake and transport of the toxins in yeast and C. elegans and use chemical genomics approaches to identify the cellular pathways affected by these toxins. The ideal candidate should have a Ph.D. in a related field, experience with yeast and/or C.elegans genetics and cell biology and familiarity with chemical biology approaches. The Biotech Center is located in New Brunswick, New Jersey near New York City and Philadelphia and is equipped with state-of-the-art facilities and instrumentation. Rutgers University is an equal opportunity employer that strongly encourages underrepresented groups to apply for open positions.

Interested applicants should send their CV and names and addresses of three references to Dr. Nilgun E. Tumer (tumer@aesop.rutgers.edu). Information on our research can be found at: http://biotech.rutgers.edu/faculty/tumer.html, http://aesop.rutgers.edu/~plantbiopath/faculty/tumer/TUMER.HTML, http://lifesci.rutgers.edu/~molbiosci/faculty/tumer.html Contact: Nilgun Tumer, Foran Hall, Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520. Tel: 732-932-8165 X215.

Postdoctoral Position, Chemical Genomics

Research Department: Molecular Ligand Target Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute Dr. Charles Boone, Visiting Scientist Dr. Minoru Yoshida, Team Leader

Location: RIKEN Advanced Science Institute, RIKEN Wako Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan

Area of Research: Chemical genetics and chemical genomics

Job Description: A postdoctoral researcher position is open in the field of chemical genomics. We have constructed a unique chemical library based on natural products in the Department of Chemical Biology, RIKAN Advanced Science Institute. The successful candidate will carry out original research on global analysis of drug-target interaction using the chemical library and various yeast mutants or transformants.

Selection Process: Candidates will be selected based on research results, publications, letters of recommendation (preferably in English), etc. The CV (preferably detailed and complete) and publications must be in English.

Application Deadline: Applications are now being accepted. Position will be closed after a suitable candidate is found.

Start of Employment: Immediately

Contract Conditions: Full-time employment with the contract shall be for one year, renewable annually upon evaluation until the end of the project (March 2012). Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Moving expenses to RIKEN will be reimbursed. Social insurance will also be applicable. Days off include public holidays, New Year's holidays (Dec. 29-Jan 3), summer holidays and RIKEN Foundation Day. These and other employment provisions are in accordance with RIKEN regulations.

Information at Web: Information on our team can be found on our website (http://www.riken.go.jp/engn/r-world/research/lab/asi/chemical/index.html)

Applications: Electronic copies of your curriculum vitae/résumé, a list of publications, two or three representative publications, and two reference letters should be sent to the address below or via e-mail to "charlie.boone" (add @utoronto.ca" to complete the address): Charles Boone Professor, University of Toronto, Donnelly CCBR 160 College St, Rm 1306 Toronto, ON M5S 3E1

Notes: The documents you submit will be handled with the utmost care in accordance with RIKEN's rules for the protection of personal data and will be used only for employment screening purposes. This information will not be divulged, assigned, or loaned to a third party without legitimate reason.

Postdoctoral Position: Engineering sea lamprey antibodies

A vacant postdoctoral position at the Center of Marine Biotechnology in Baltimore to characterize antigen binding properties of VLR, the unique variable lymphocyte receptors of sea lamprey. The successful candidate will join a study with the goal to explore biotechnology applications for these novel antibodies (Pancer & Mariuzza, Nat. Biotechnol., 2008; Rogozin et al., Nat. Immunol., 2007; Alder et al., Science 2005; Pancer et al., Nature 2004). Our research platform includes yeast displayed recombinant VLR libraries that are screened with various antigens. Biochemical and structural properties of monoclonal VLRs are then characterized.

Candidates must have a PhD with solid background in protein biochemistry and molecular biology, experience in recombinant protein expression and characterization, and relevant peer-reviewed publications.

To apply for position #300957 please submit a letter describing your research interests and experience, an updated curriculum vitae and names of three references via http://www.cytiva.com/umbi/ext/detail.asp?jobid=umbi300957

Contact: Zeev Pancer, PhD Center of Marine Biotechnology, UMBI Columbus Center, Suite 236 701 East Pratt St. Baltimore, MD 21202, USA Office: 410-234-8834; Fax: 410-234-8896 Email: pancer@comb.umbi.umd.edu

Epigenetic Postdoctoral Fellow Posting

Postdoctoral positions are available at Massachusetts General Hospital Cancer Center. My laboratory is focused on understanding the impact that both methylation and acetylation dynamics has in both human cell culture and C. elegans. In particular, the laboratory is investigating the impact that the histone 3 lysine 9/36 tri-demethylases [JMJD2A-D; Whetstine et al., (2007) Cell 125: 467-81] have on tumorigenesis, transcriptional regulation, and genomic integrity. The laboratory will interrogate the role of these enzymes by using genomic, proteomic, cytological and genetic approaches. Similar approaches allowed an important link to be established for histone deacetylase 1 (HDAC-1) and the regulation of extra-cellular matrix biology in both human and C. elegans, which has direct implications in cancer chemotherapy [Whetstine et al., (2005) Mol. Cell 18:483-90]. The laboratory will continue to investigate the functional overlap or unique pathways that the C. elegans class I histone deacetylases regulate by using the same type of approaches. Overall, the laboratory will integrate a number of approaches and systems to determine the important biological pathways regulated by histone demethylases and histone deacetylases.

The laboratory is looking for highly motivated, tenacious scientists that are enthusiastic, team players and love science. The laboratory is looking for researchers with documented proficiency in any of the following areas (basic molecular biology, protein biochemistry, genomics, epigenetics, C. elegans, cytology, development biology, DNA damage and repair) but interested in learning new approaches or systems to answer the exciting questions before us.

Requirements: For these positions a Ph.D. and/or M.D. is required. These positions require enthusiastic, self motivated, independent thinkers with strong interpersonal skills, and the ability to communicate with laboratory members, national and international collaborators. Please have three letters of recommendation sent to the below address and/or e-mail.

Johnathan R. Whetstine, Ph.D. Assistant Professor of Medicine Harvard Medical School and Massachusetts General Hospital Cancer Center Building 149, 13th Street , Room 7-213 Charlestown, MA 02129, USA Office Phone: 617-643-4374 jwhetstine@hms.harvard.edu

B.A./B.S. Yeast Biochemist at Gevo, Inc., Englewood, CO, USA

Gevo, Inc. is a high energy, team-oriented company that is pioneering the advanced green energy industry. We are looking for a term (up to one year) Biocatalyst Development Biochemist, based in Englewood, Colorado. This role is responsible for execution of analysis of metabolites on yeast biocatalysts under the direction of a senior scientist. This person will characterize yeast biocatalysts for their intra- and extracellular metabolite production, genotypes, and phenotypes. This position is considered a term position for up to one year.

Requirements include: Bachelor degree in Biochemistry, Chemistry, Biotechnology, Microbiology or related field and 1 – 3 years of professional work experience in a lab, working with biochemical techniques and yeast. A detailed job description can be found at [3]