Difference between revisions of "YMR001C"
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| − | '''Description of YMR001C:''' Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; | + | '''Description of YMR001C:''' Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate<ref name='S000074718'>Alexandru G, et al. (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72 {{SGDpaper|S000074718}} PMID 11371343</ref><ref name='S000073294'>Hu F and Elledge SJ (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5 {{SGDpaper|S000073294}} PMID 12461298</ref><ref name='S000133454'>Iacovella MG, et al. (2010) Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint. Cell Cycle 9(6) {{SGDpaper|S000133454}} PMID 20237423</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
{{SGDpaper|S000074306}} PMID 14574415</ref> | {{SGDpaper|S000074306}} PMID 14574415</ref> | ||
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Revision as of 13:05, 7 September 2010
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| Systematic name | YMR001C |
| Gene name | CDC5 |
| Aliases | MSD2, PKX2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:271136..269019 |
| Primary SGDID | S000004603 |
Description of YMR001C: Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Alexandru G, et al. (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72 SGD PMID 11371343
- ↑ Hu F and Elledge SJ (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5 SGD PMID 12461298
- ↑ Iacovella MG, et al. (2010) Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint. Cell Cycle 9(6) SGD PMID 20237423
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-29
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