Difference between revisions of "YEL031W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000757 YEL031W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000757 YEL031W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SPF1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SPF1 ''

Revision as of 06:45, 23 January 2012

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Systematic name YEL031W
Gene name SPF1
Aliases COD1, PER9, PIO1
Feature type ORF, Verified
Coordinates Chr V:90258..93905
Primary SGDID S000000757


Description of YEL031W: P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1[1][2][3]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Genotype: RHY1202
Phenotype(s): Loss of function (Null), Recessive, Viable

Deletion of COD1/SPF1 prevents the degradation of Hmg2p from being regulated. [1] [4]





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References

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  1. 1.0 1.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
  2. Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
  3. Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23 SGD PMID 10361284
  4. submitted by Stephen R. Cronin on 2003-06-13

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