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| − | === Alleles, Strains, and Phenotypes ===
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| − | [[Category:Topic:Alleles, Strains, and Phenotypes]]
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| − | ==== Point Mutation ====
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| − | [[Category:Topic:Alleles, Strains, and Phenotypes:Point Mutation]]
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| − | '''Allele''': mtw1-1<br>
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| − |
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| − | '''Strain Background''': W303<br>
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| − | '''Phenotype(s)''': Temperature(Heat) Sensitive [[Category:Phenotype:Temperature(Heat) Sensitive]]
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| − |
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| − | mtw1-1 mutants activate the spindle checkpoint in an IPL1 dependent manner. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | '''Allele''': mtw1-1<br>
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| − |
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| − | '''Strain Background''': W303<br>
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| − | '''Phenotype(s)''': Temperature(Heat) Sensitive [[Category:Phenotype:Temperature(Heat) Sensitive]]
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| − |
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| − | mtw1-1 mutants have unattached chromosomes. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | === Interactions ===
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| − | [[Category:Topic:Interactions]]
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| − | ==== Genetic ====
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| − | [[Category:Topic:Interactions:Genetic]]
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| − | YAL034W-A is suppressed by DSN1 [[Category:Genetic Interaction with DSN1]]
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| − |
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| − |
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| − | '''Strain Background''': W303<br>
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| − |
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| − | DSN1 is a high copy suppressor of the mtw1-1 mutant. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | ==== Physical ====
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| − | [[Category:Topic:Interactions:Physical]]
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| − | Physical interaction with CSE4 [[Category:Physical Interactions with CSE4]]<br>
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| − | Cse4p co-immunoprecipitates with Mtw1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with DSN1 [[Category:Physical Interactions with DSN1]]<br>
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| − | Mtw1p co-immunoprecipitates Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| | __TOC__ | | __TOC__ |
| | ==Community Commentary== | | ==Community Commentary== |
Revision as of 10:51, 24 January 2007
Share your knowledge...Edit this entry!
| Systematic name |
YAL034W-A
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| Gene name |
MTW1
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| Aliases |
DSN3, NSL2
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| Feature type |
ORF, Verified
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| Coordinates
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Chr I:79719..80588
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| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs.
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Description of YAL034W-A: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly[1]
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Alleles, Strains, and Phenotypes
Point Mutation
Allele: mtw1-1
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
mtw1-1 mutants activate the spindle checkpoint in an IPL1 dependent manner. [2] [3]
Allele: mtw1-1
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
mtw1-1 mutants have unattached chromosomes. [2] [3]
Interactions
Genetic
YAL034W-A is suppressed by DSN1
Strain Background: W303
DSN1 is a high copy suppressor of the mtw1-1 mutant. [2] [3]
Physical
Physical interaction with CSE4
Cse4p co-immunoprecipitates with Mtw1p. [2] [3]
Physical interaction with DSN1
Mtw1p co-immunoprecipitates Dsn1p. [2] [3]
References
See Help:References on how to add references
- ↑ De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21
SGD PMID 14633972
- ↑ 2.0 2.1 2.2 2.3 2.4 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 3.0 3.1 3.2 3.3 3.4 submitted by Benjamin Pinsky on 2004-03-04
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