Difference between revisions of "YLR450W"
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| − | '''Description of YLR450W:''' One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks | + | '''Description of YLR450W:''' One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks<ref name='S000048924'>Basson ME, et al. (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7 {{SGDpaper|S000048924}} PMID 3526336</ref><ref name='S000055806'>Koning AJ, et al. (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89 {{SGDpaper|S000055806}} PMID 8744950</ref><ref name='S000039432'>Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 {{SGDpaper|S000039432}} PMID 7791530</ref><ref name='S000050136'>Wright R, et al. (1988) Increased amounts of HMG-CoA reductase induce karmellae: a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14 |
| − | {{SGDpaper| | + | {{SGDpaper|S000050136}} PMID 3292536</ref> |
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Revision as of 13:05, 25 February 2010
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| Systematic name | YLR450W |
| Gene name | HMG2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:1032624..1035761 |
| Primary SGDID | S000004442 |
Description of YLR450W: One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks[1][2][3][4]
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References
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- ↑ Basson ME, et al. (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7 SGD PMID 3526336
- ↑ Koning AJ, et al. (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89 SGD PMID 8744950
- ↑ Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 SGD PMID 7791530
- ↑ Wright R, et al. (1988) Increased amounts of HMG-CoA reductase induce karmellae: a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14 SGD PMID 3292536
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