Difference between revisions of "YKR072C"

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'''Description of YKR072C:''' Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression<ref name='S000054046'>de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 {{SGDpaper|S000054046}} PMID 9636153</ref><ref name='S000069831'>Yenush L, et al. (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9
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'''Description of YKR072C:''' Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis<ref name='S000054046'>de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 {{SGDpaper|S000054046}} PMID 9636153</ref><ref name='S000069831'>Yenush L, et al. (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9 {{SGDpaper|S000069831}} PMID 11867520</ref><ref name='S000132230'>Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8
  {{SGDpaper|S000069831}} PMID 11867520</ref>
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  {{SGDpaper|S000132230}} PMID 19915539</ref>
 
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Revision as of 13:05, 18 December 2009

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Systematic name YKR072C
Gene name SIS2
Aliases HAL3
Feature type ORF, Verified
Coordinates Chr XI:577765..576077
Primary SGDID S000001780


Description of YKR072C: Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis[1][2][3]




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References

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  1. de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 SGD PMID 9636153
  2. Yenush L, et al. (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9 SGD PMID 11867520
  3. Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 SGD PMID 19915539

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