Difference between revisions of "YHR178W"

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'''Description of YHR178W:''' Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay<ref name='S000054148'>Kasten MM and Stillman DJ (1997) Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins. Mol Gen Genet 256(4):376-86 {{SGDpaper|S000054148}} PMID 9393435</ref><ref name='S000076583'>Akache B, et al. (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60
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'''Description of YHR178W:''' Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro<ref name='S000054148'>Kasten MM and Stillman DJ (1997) Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins. Mol Gen Genet 256(4):376-86 {{SGDpaper|S000054148}} PMID 9393435</ref><ref name='S000076583'>Akache B, et al. (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60 {{SGDpaper|S000076583}} PMID 15123673</ref><ref name='S000117952'>Larochelle M, et al. (2006) Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production. Mol Cell Biol 26(17):6690-701
  {{SGDpaper|S000076583}} PMID 15123673</ref>
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  {{SGDpaper|S000117952}} PMID 16914749</ref>
 
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Revision as of 13:05, 4 August 2009

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Systematic name YHR178W
Gene name STB5
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:459299..461530
Primary SGDID S000001221


Description of YHR178W: Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro[1][2][3]




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References

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  1. Kasten MM and Stillman DJ (1997) Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins. Mol Gen Genet 256(4):376-86 SGD PMID 9393435
  2. Akache B, et al. (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60 SGD PMID 15123673
  3. Larochelle M, et al. (2006) Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production. Mol Cell Biol 26(17):6690-701 SGD PMID 16914749

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