Difference between revisions of "YOR076C"

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'''Description of YOR076C:''' Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs<ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000042674'>Peltz SW, et al. (1999) Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol 19(1):384-91
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'''Description of YOR076C:''' Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype<ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900
{{SGDpaper|S000042674}} PMID 9858562</ref>
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{{SGDpaper|S000052117}} PMID 10074137</ref>
 
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Revision as of 13:05, 19 March 2009

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Systematic name YOR076C
Gene name SKI7
Aliases YOR29-27
Feature type ORF, Verified
Coordinates Chr XV:471622..469379
Primary SGDID S000005602


Description of YOR076C: Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype[1][2][3][4][5]




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References

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  1. Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 SGD PMID 16043509
  2. van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 SGD PMID 11910110
  3. Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 SGD PMID 11532933
  4. van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 SGD PMID 11027292
  5. Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 SGD PMID 10074137

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