Difference between revisions of "YDR439W"
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| − | '''Description of YDR439W:''' | + | '''Description of YDR439W:''' Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation<ref name='S000054483'>Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 {{SGDpaper|S000054483}} PMID 10082585</ref><ref name='S000073065'>Rabitsch KP, et al. (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48 {{SGDpaper|S000073065}} PMID 12689592</ref><ref name='S000129985'>Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35 |
| − | {{SGDpaper| | + | {{SGDpaper|S000129985}} PMID 19362534</ref> |
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Revision as of 13:05, 27 April 2009
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| Systematic name | YDR439W |
| Gene name | LRS4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1339669..1340712 |
| Primary SGDID | S000002847 |
Description of YDR439W: Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 SGD PMID 10082585
- ↑ Rabitsch KP, et al. (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48 SGD PMID 12689592
- ↑ Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35 SGD PMID 19362534
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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