Difference between revisions of "YLR451W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004443 YLR451W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''LEU3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''LEU3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:1036093..1038753 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004443 |
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| − | '''Description of | + | '''Description of YLR451W:''' Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation<ref name='S000051008'>Friden P and Schimmel P (1987) LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Mol Cell Biol 7(8):2708-17 {{SGDpaper|S000051008}} PMID 2823102</ref><ref name='S000039652'>Friden P and Schimmel P (1988) LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence. Mol Cell Biol 8(7):2690-7 {{SGDpaper|S000039652}} PMID 3043190</ref><ref name='S000055502'>Sze JY, et al. (1992) In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science 258(5085):1143-5 {{SGDpaper|S000055502}} PMID 1439822</ref><ref name='S000042858'>Zhou K, et al. (1987) Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control. Nucleic Acids Res 15(13):5261-73 {{SGDpaper|S000042858}} PMID 3299266</ref><ref name='S000049861'>Zhou KM, et al. (1990) Yeast regulatory protein LEU3: a structure-function analysis. Nucleic Acids Res 18(2):291-8 |
| − | {{SGDpaper| | + | {{SGDpaper|S000049861}} PMID 2183176</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLR451W |
| Gene name | LEU3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:1036093..1038753 |
| Primary SGDID | S000004443 |
Description of YLR451W: Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation[1][2][3][4][5]
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Contents
Community Commentary
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References
See Help:References on how to add references
- ↑ Friden P and Schimmel P (1987) LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Mol Cell Biol 7(8):2708-17 SGD PMID 2823102
- ↑ Friden P and Schimmel P (1988) LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence. Mol Cell Biol 8(7):2690-7 SGD PMID 3043190
- ↑ Sze JY, et al. (1992) In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science 258(5085):1143-5 SGD PMID 1439822
- ↑ Zhou K, et al. (1987) Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control. Nucleic Acids Res 15(13):5261-73 SGD PMID 3299266
- ↑ Zhou KM, et al. (1990) Yeast regulatory protein LEU3: a structure-function analysis. Nucleic Acids Res 18(2):291-8 SGD PMID 2183176
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