Difference between revisions of "YLR242C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004232 YLR242C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ARV1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ARV1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:623883..622918 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004232 |
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| − | '''Description of | + | '''Description of YLR242C:''' Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p<ref name='S000125620'>Kajiwara K, et al. (2008) Yeast ARV1 Is Required for Efficient Delivery of an Early GPI Intermediate to the First Mannosyltransferase during GPI Assembly and Controls Lipid Flow from the Endoplasmic Reticulum. Mol Biol Cell 19(5):2069-82 {{SGDpaper|S000125620}} PMID 18287539</ref><ref name='S000071418'>Swain E, et al. (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60 {{SGDpaper|S000071418}} PMID 12145310</ref><ref name='S000059466'>Tinkelenberg AH, et al. (2000) Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem 275(52):40667-70 {{SGDpaper|S000059466}} PMID 11063737</ref><ref name='S000135235'>Tong F, et al. (2010) Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. J Biol Chem 285(44):33632-41 |
| − | {{SGDpaper| | + | {{SGDpaper|S000135235}} PMID 20663892</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLR242C |
| Gene name | ARV1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:623883..622918 |
| Primary SGDID | S000004232 |
Description of YLR242C: Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p[1][2][3][4]
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Community Commentary
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References
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- ↑ Kajiwara K, et al. (2008) Yeast ARV1 Is Required for Efficient Delivery of an Early GPI Intermediate to the First Mannosyltransferase during GPI Assembly and Controls Lipid Flow from the Endoplasmic Reticulum. Mol Biol Cell 19(5):2069-82 SGD PMID 18287539
- ↑ Swain E, et al. (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60 SGD PMID 12145310
- ↑ Tinkelenberg AH, et al. (2000) Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem 275(52):40667-70 SGD PMID 11063737
- ↑ Tong F, et al. (2010) Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. J Biol Chem 285(44):33632-41 SGD PMID 20663892
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