Difference between revisions of "YJL164C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003700 YJL164C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TPK1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TPK1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr X: | + | |nowrap| Chr X:111159..109966 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003700 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003700 | ||
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| − | '''Description of YJL164C:''' cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p<ref name=' | + | '''Description of YJL164C:''' cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p<ref name='S000042460'>Ordiz I, et al. (1996) Glucose-induced inactivation of isocitrate lyase in Saccharomyces cerevisiae is mediated by the cAMP-dependent protein kinase catalytic subunits Tpk1 and Tpk2. FEBS Lett 385(1-2):43-6 {{SGDpaper|S000042460}} PMID 8641464</ref><ref name='S000043708'>Toda T, et al. (1987) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7(4):1371-7 {{SGDpaper|S000043708}} PMID 3037314</ref><ref name='S000042132'>Toda T, et al. (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50(2):277-87 |
{{SGDpaper|S000042132}} PMID 3036373</ref> | {{SGDpaper|S000042132}} PMID 3036373</ref> | ||
<br> | <br> | ||
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[[Category:Topic:Interactions:Genetic]] | [[Category:Topic:Interactions:Genetic]] | ||
| − | '''Strain Background''': S288C, W303, industrial<br> | + | '''Strain Background''': S288C, W303 (''see [[CommunityW303.html|detailed notes]] from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study''), industrial<br> |
Genetic interaction with ATF1 [[Category:Genetic Interactions with ATF1]]<br>'''Mutation type(s)''': deletion/partial inactivating | Genetic interaction with ATF1 [[Category:Genetic Interactions with ATF1]]<br>'''Mutation type(s)''': deletion/partial inactivating | ||
Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YJL164C |
| Gene name | TPK1 |
| Aliases | PKA1, SRA3 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:111159..109966 |
| Primary SGDID | S000003700 |
Description of YJL164C: cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p[1][2][3]
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Community Commentary
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Interactions
Genetic
Strain Background: S288C, W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study), industrial
Genetic interaction with ATF1
Mutation type(s): deletion/partial inactivating
ATF1 is transcriptionally induced by glucose and sucrose. This regulation depends on Ras/cAMP/PKA signaling. Long-term expression of ATF1 requires both a fermentable carbon source and a nitrogen source. This regulation depends on FGM signaling. [4] [5]
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References
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- ↑ Ordiz I, et al. (1996) Glucose-induced inactivation of isocitrate lyase in Saccharomyces cerevisiae is mediated by the cAMP-dependent protein kinase catalytic subunits Tpk1 and Tpk2. FEBS Lett 385(1-2):43-6 SGD PMID 8641464
- ↑ Toda T, et al. (1987) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7(4):1371-7 SGD PMID 3037314
- ↑ Toda T, et al. (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50(2):277-87 SGD PMID 3036373
- ↑ Verstrepen KJ, et al. (2003) The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways. FEMS Yeast Res 4(3):285-96 SGD PMID 14654433
- ↑ submitted by Kevin J Verstrepen on 2004-03-04
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