Difference between revisions of "YKL108W"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001591 YKL108W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SLD2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SLD2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
− | |nowrap| Chr XI: | + | |nowrap| Chr XI:234426..235787 |
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− | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001591 |
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− | '''Description of | + | '''Description of YKL108W:''' Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint<ref name='S000146691'>Bruck I, et al. (2011) Enabling association of the GINS tetramer with the Mcm2-7 complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem () {{SGDpaper|S000146691}} PMID 21868389</ref><ref name='S000145995'>Kanter DM and Kaplan DL (2011) Sld2 binds to origin single-stranded DNA and stimulates DNA annealing. Nucleic Acids Res 39(7):2580-92 {{SGDpaper|S000145995}} PMID 21109535</ref><ref name='S000069125'>Masumoto H, et al. (2002) S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415(6872):651-5 {{SGDpaper|S000069125}} PMID 11807498</ref><ref name='S000133496'>Muramatsu S, et al. (2010) CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol {varepsilon}, and GINS in budding yeast. Genes Dev 24(6):602-12 {{SGDpaper|S000133496}} PMID 20231317</ref><ref name='S000120052'>Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 {{SGDpaper|S000120052}} PMID 17167415</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000132428'>Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 |
− | {{SGDpaper| | + | {{SGDpaper|S000132428}} PMID 17167417</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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+ | === Protein Details === | ||
+ | [[Category:Topic:Protein Details]] | ||
+ | ==== Protein Modification ==== | ||
+ | [[Category:Topic:Protein Details:Protein Modification]] | ||
+ | '''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]] | ||
+ | |||
+ | Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref> | ||
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+ | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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+ | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
+ | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
+ | J Biol Chem 278(5):3265-74</ref> | ||
+ | --> | ||
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+ | <protect> | ||
==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
Systematic name | YKL108W |
Gene name | SLD2 |
Aliases | DRC1 |
Feature type | ORF, Verified |
Coordinates | Chr XI:234426..235787 |
Primary SGDID | S000001591 |
Description of YKL108W: Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint[1][2][3][4][5][6][7][8]
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Community Commentary
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [9]
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References
See Help:References on how to add references
- ↑ Bruck I, et al. (2011) Enabling association of the GINS tetramer with the Mcm2-7 complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem () SGD PMID 21868389
- ↑ Kanter DM and Kaplan DL (2011) Sld2 binds to origin single-stranded DNA and stimulates DNA annealing. Nucleic Acids Res 39(7):2580-92 SGD PMID 21109535
- ↑ Masumoto H, et al. (2002) S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415(6872):651-5 SGD PMID 11807498
- ↑ Muramatsu S, et al. (2010) CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol {varepsilon}, and GINS in budding yeast. Genes Dev 24(6):602-12 SGD PMID 20231317
- ↑ Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 SGD PMID 17167415
- ↑ 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 SGD PMID 10097122
- ↑ Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 SGD PMID 17167417
- ↑ submitted by Jeff Ubersax on 2004-01-27
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