Difference between revisions of "YLR022C"
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{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004012 YLR022C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SDO1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SDO1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:184926..184174 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004012 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004012 | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YLR022C:''' Essential protein involved in | + | '''Description of YLR022C:''' Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes<ref name='S000115063'>Boocock GR, et al. (2006) Phylogeny, sequence conservation, and functional complementation of the SBDS protein family. Genomics 87(6):758-71 {{SGDpaper|S000115063}} PMID 16529906</ref><ref name='S000145759'>Finch AJ, et al. (2011) Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev 25(9):917-29 {{SGDpaper|S000145759}} PMID 21536732</ref><ref name='S000121870'>Menne TF, et al. (2007) The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet 39(4):486-95 {{SGDpaper|S000121870}} PMID 17353896</ref><ref name='S000080732'>Savchenko A, et al. (2005) The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. J Biol Chem 280(19):19213-20 {{SGDpaper|S000080732}} PMID 15701634</ref><ref name='S000080728'>Shammas C, et al. (2005) Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome. J Biol Chem 280(19):19221-9 |
{{SGDpaper|S000080728}} PMID 15701631</ref> | {{SGDpaper|S000080728}} PMID 15701631</ref> | ||
<br> | <br> | ||
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{{CommentaryHelp}} | {{CommentaryHelp}} | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
| + | --> | ||
Latest revision as of 13:05, 29 February 2012
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| Systematic name | YLR022C |
| Gene name | SDO1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:184926..184174 |
| Primary SGDID | S000004012 |
Description of YLR022C: Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes[1][2][3][4][5]
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References
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- ↑ Boocock GR, et al. (2006) Phylogeny, sequence conservation, and functional complementation of the SBDS protein family. Genomics 87(6):758-71 SGD PMID 16529906
- ↑ Finch AJ, et al. (2011) Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev 25(9):917-29 SGD PMID 21536732
- ↑ Menne TF, et al. (2007) The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet 39(4):486-95 SGD PMID 17353896
- ↑ Savchenko A, et al. (2005) The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. J Biol Chem 280(19):19213-20 SGD PMID 15701634
- ↑ Shammas C, et al. (2005) Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome. J Biol Chem 280(19):19221-9 SGD PMID 15701631
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