Difference between revisions of "YGR184C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003416 YGR184C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''UBR1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''UBR1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:865753..859901 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003416 |
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| − | '''Description of | + | '''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000044765'>Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 {{SGDpaper|S000044765}} PMID 9427760</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000126742'>Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 {{SGDpaper|S000126742}} PMID 18566452</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000132192'>Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 |
| − | {{SGDpaper| | + | {{SGDpaper|S000132192}} PMID 16311597</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR184C |
| Gene name | UBR1 |
| Aliases | PTR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:865753..859901 |
| Primary SGDID | S000003416 |
Description of YGR184C: E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)[1][2][3][4][5][6]
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Contents
Community Commentary
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References
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- ↑ Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 SGD PMID 2209542
- ↑ Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 SGD PMID 9427760
- ↑ Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 SGD PMID 1651502
- ↑ Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 SGD PMID 18566452
- ↑ Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 SGD PMID 10688918
- ↑ Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 SGD PMID 16311597
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