Difference between revisions of "YGL175C"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003143 YGL175C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SAE2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SAE2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
− | |nowrap| Chr VII: | + | |nowrap| Chr VII:174322..173285 |
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− | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003143 |
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− | '''Description of | + | '''Description of YGL175C:''' Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents<ref name='S000076515'>Baroni E, et al. (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24(10):4151-65 {{SGDpaper|S000076515}} PMID 15121837</ref><ref name='S000124863'>Lengsfeld BM, et al. (2007) Sae2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre11/Rad50/Xrs2 Complex. Mol Cell 28(4):638-51 {{SGDpaper|S000124863}} PMID 18042458</ref><ref name='S000045008'>McKee AH and Kleckner N (1997) A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146(3):797-816 {{SGDpaper|S000045008}} PMID 9215888</ref><ref name='S000045005'>Prinz S, et al. (1997) Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146(3):781-95 {{SGDpaper|S000045005}} PMID 9215887</ref><ref name='S000060386'>Rattray AJ, et al. (2001) Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158(1):109-22 |
− | {{SGDpaper| | + | {{SGDpaper|S000060386}} PMID 11333222</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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+ | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
+ | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
+ | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
Systematic name | YGL175C |
Gene name | SAE2 |
Aliases | COM1 |
Feature type | ORF, Verified |
Coordinates | Chr VII:174322..173285 |
Primary SGDID | S000003143 |
Description of YGL175C: Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents[1][2][3][4][5]
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Community Commentary
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References
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- ↑ Baroni E, et al. (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24(10):4151-65 SGD PMID 15121837
- ↑ Lengsfeld BM, et al. (2007) Sae2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre11/Rad50/Xrs2 Complex. Mol Cell 28(4):638-51 SGD PMID 18042458
- ↑ McKee AH and Kleckner N (1997) A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146(3):797-816 SGD PMID 9215888
- ↑ Prinz S, et al. (1997) Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146(3):781-95 SGD PMID 9215887
- ↑ Rattray AJ, et al. (2001) Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158(1):109-22 SGD PMID 11333222
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