Difference between revisions of "YGL178W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003146 YGL178W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MPT5 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MPT5 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:167352..170571 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003146 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003146 | ||
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| − | '''Description of YGL178W:''' | + | '''Description of YGL178W:''' mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity<ref name='S000051164'>Chen T and Kurjan J (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17(6):3429-39 {{SGDpaper|S000051164}} PMID 9154842</ref><ref name='S000135616'>Cridge AG, et al. (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res 38(22):8039-50 {{SGDpaper|S000135616}} PMID 20705650</ref><ref name='S000075705'>Gerber AP, et al. (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79 {{SGDpaper|S000075705}} PMID 15024427</ref><ref name='S000116044'>Goldstrohm AC, et al. (2006) PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol 13(6):533-9 {{SGDpaper|S000116044}} PMID 16715093</ref><ref name='S000069081'>Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 {{SGDpaper|S000069081}} PMID 11805047</ref><ref name='S000040351'>Kennedy BK, et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91 {{SGDpaper|S000040351}} PMID 9150138</ref><ref name='S000120287'>Stewart MS, et al. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryot Cell 6(2):262-70 {{SGDpaper|S000120287}} PMID 17172436</ref><ref name='S000059468'>Tadauchi T, et al. (2001) Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J 20(3):552-61 {{SGDpaper|S000059468}} PMID 11157761</ref><ref name='S000134222'>Traven A, et al. (2010) The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS One 5(5):e10651 |
| − | {{SGDpaper| | + | {{SGDpaper|S000134222}} PMID 20498834</ref> |
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Latest revision as of 13:05, 7 March 2012
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| Systematic name | YGL178W |
| Gene name | MPT5 |
| Aliases | HTR1, PUF5, UTH4 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:167352..170571 |
| Primary SGDID | S000003146 |
Description of YGL178W: mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity[1][2][3][4][5][6][7][8][9]
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References
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- ↑ Chen T and Kurjan J (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17(6):3429-39 SGD PMID 9154842
- ↑ Cridge AG, et al. (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res 38(22):8039-50 SGD PMID 20705650
- ↑ Gerber AP, et al. (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79 SGD PMID 15024427
- ↑ Goldstrohm AC, et al. (2006) PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol 13(6):533-9 SGD PMID 16715093
- ↑ Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 SGD PMID 11805047
- ↑ Kennedy BK, et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91 SGD PMID 9150138
- ↑ Stewart MS, et al. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryot Cell 6(2):262-70 SGD PMID 17172436
- ↑ Tadauchi T, et al. (2001) Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J 20(3):552-61 SGD PMID 11157761
- ↑ Traven A, et al. (2010) The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS One 5(5):e10651 SGD PMID 20498834
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