Difference between revisions of "YFL037W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001857 YFL037W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TUB2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TUB2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VI: | + | |nowrap| Chr VI:56336..57709 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001857 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001857 | ||
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| − | '''Description of YFL037W:''' Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules<ref name='S000057282'>Neff NF, et al. (1983) Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell 33(1):211-9 | + | '''Description of YFL037W:''' Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria<ref name='S000151180'>Cederquist GY, et al. (2012) An inherited TUBB2B mutation alters a kinesin binding site and causes polymicrogyria, CFEOM, and axon dysinnervation. Hum Mol Genet () {{SGDpaper|S000151180}} PMID 23001566</ref><ref name='S000057282'>Neff NF, et al. (1983) Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell 33(1):211-9 |
{{SGDpaper|S000057282}} PMID 6380751</ref> | {{SGDpaper|S000057282}} PMID 6380751</ref> | ||
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Latest revision as of 13:05, 23 October 2012
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| Systematic name | YFL037W |
| Gene name | TUB2 |
| Aliases | ARM10, SHE8 |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:56336..57709 |
| Primary SGDID | S000001857 |
Description of YFL037W: Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria[1][2]
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References
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- ↑ Cederquist GY, et al. (2012) An inherited TUBB2B mutation alters a kinesin binding site and causes polymicrogyria, CFEOM, and axon dysinnervation. Hum Mol Genet () SGD PMID 23001566
- ↑ Neff NF, et al. (1983) Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell 33(1):211-9 SGD PMID 6380751
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