Difference between revisions of "YER169W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000971 YER169W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPH1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPH1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr V: | + | |nowrap| Chr V:523369..525759 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000971 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000971 | ||
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| − | '''Description of YER169W:''' | + | '''Description of YER169W:''' JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway<ref name='S000046845'>Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 {{SGDpaper|S000046845}} PMID 10523651</ref><ref name='S000069126'>Kim EM, et al. (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8 {{SGDpaper|S000069126}} PMID 11809875</ref><ref name='S000121953'>Klose RJ, et al. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61 {{SGDpaper|S000121953}} PMID 17371840</ref><ref name='S000145815'>Kwon DW and Ahn SH (2011) Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Biochem Biophys Res Commun () {{SGDpaper|S000145815}} PMID 21684259</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 |
| − | {{SGDpaper| | + | {{SGDpaper|S000121921}} PMID 17369256</ref> |
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YER169W |
| Gene name | RPH1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:523369..525759 |
| Primary SGDID | S000000971 |
Description of YER169W: JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway[1][2][3][4][5]
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References
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- ↑ Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 SGD PMID 10523651
- ↑ Kim EM, et al. (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8 SGD PMID 11809875
- ↑ Klose RJ, et al. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61 SGD PMID 17371840
- ↑ Kwon DW and Ahn SH (2011) Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Biochem Biophys Res Commun () SGD PMID 21684259
- ↑ Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256
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