Difference between revisions of "YBR098W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000302 YBR098W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MMS4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MMS4 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr II: | + | |nowrap| Chr II:441515..443590 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000302 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000302 | ||
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| − | '''Description of YBR098W:''' Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination | + | '''Description of YBR098W:''' Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p<ref name='S000073248'>Bastin-Shanower SA, et al. (2003) The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol 23(10):3487-96 {{SGDpaper|S000073248}} PMID 12724407</ref><ref name='S000150006'>Gallo-Fernandez M, et al. (2012) Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res () {{SGDpaper|S000150006}} PMID 22730299</ref><ref name='S000127423'>Jessop L and Lichten M (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31(3):313-23 {{SGDpaper|S000127423}} PMID 18691964</ref><ref name='S000068964'>Kaliraman V, et al. (2001) Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev 15(20):2730-40 {{SGDpaper|S000068964}} PMID 11641278</ref><ref name='S000127369'>Oh SD, et al. (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31(3):324-36 {{SGDpaper|S000127369}} PMID 18691965</ref><ref name='S000044724'>Xiao W, et al. (1998) Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage. Mol Gen Genet 257(6):614-23 |
{{SGDpaper|S000044724}} PMID 9604884</ref> | {{SGDpaper|S000044724}} PMID 9604884</ref> | ||
<br> | <br> | ||
Latest revision as of 13:05, 24 July 2012
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| Systematic name | YBR098W |
| Gene name | MMS4 |
| Aliases | SLX2, YBR100W |
| Feature type | ORF, Verified |
| Coordinates | Chr II:441515..443590 |
| Primary SGDID | S000000302 |
Description of YBR098W: Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p[1][2][3][4][5][6]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [8]
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References
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- ↑ Bastin-Shanower SA, et al. (2003) The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol 23(10):3487-96 SGD PMID 12724407
- ↑ Gallo-Fernandez M, et al. (2012) Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res () SGD PMID 22730299
- ↑ Jessop L and Lichten M (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31(3):313-23 SGD PMID 18691964
- ↑ Kaliraman V, et al. (2001) Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev 15(20):2730-40 SGD PMID 11641278
- ↑ Oh SD, et al. (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31(3):324-36 SGD PMID 18691965
- ↑ Xiao W, et al. (1998) Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage. Mol Gen Genet 257(6):614-23 SGD PMID 9604884
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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