Difference between revisions of "YNL293W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YNL293W YNL293W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005237 YNL293W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MSB3 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MSB3 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|nowrap| Chr XIV:80640..82541
 
|nowrap| Chr XIV:80640..82541
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005237
 
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'''Description of {{PAGENAME}}:''' GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth<ref name='S000073833'>Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 {{SGDpaper|S000073833}} PMID 12913108</ref><ref name='S000056405'>Albert S and Gallwitz D (1999) Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J Biol Chem 274(47):33186-9 {{SGDpaper|S000056405}} PMID 10559187</ref><ref name='S000048044'>Bach S, et al. (2000) Co-deletion of the MSB3 and MSB4 coding regions affects bipolar budding and perturbs the organization of the actin cytoskeleton. Yeast 16(11):1015-23
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'''Description of YNL293W:''' Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p<ref name='S000056405'>Albert S and Gallwitz D (1999) Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J Biol Chem 274(47):33186-9 {{SGDpaper|S000056405}} PMID 10559187</ref><ref name='S000048044'>Bach S, et al. (2000) Co-deletion of the MSB3 and MSB4 coding regions affects bipolar budding and perturbs the organization of the actin cytoskeleton. Yeast 16(11):1015-23 {{SGDpaper|S000048044}} PMID 10923023</ref><ref name='S000073833'>Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 {{SGDpaper|S000073833}} PMID 12913108</ref><ref name='S000150869'>Lachmann J, et al. (2012) The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell 23(13):2516-26
  {{SGDpaper|S000048044}} PMID 10923023</ref>
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  {{SGDpaper|S000150869}} PMID 22593206</ref>
 
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J Biol Chem 278(5):3265-74</ref>
 
J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 13:05, 13 September 2012

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Systematic name YNL293W
Gene name MSB3
Aliases GYP3
Feature type ORF, Verified
Coordinates Chr XIV:80640..82541
Primary SGDID S000005237


Description of YNL293W: Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p[1][2][3][4]




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References

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  1. Albert S and Gallwitz D (1999) Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J Biol Chem 274(47):33186-9 SGD PMID 10559187
  2. Bach S, et al. (2000) Co-deletion of the MSB3 and MSB4 coding regions affects bipolar budding and perturbs the organization of the actin cytoskeleton. Yeast 16(11):1015-23 SGD PMID 10923023
  3. Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 SGD PMID 12913108
  4. Lachmann J, et al. (2012) The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell 23(13):2516-26 SGD PMID 22593206

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