Difference between revisions of "SGD Newsletter, Summer 2023"

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[[Category: Newsletter]]
 
[[Category: Newsletter]]
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'''About this newsletter:''' <br> This is the Summer 2023 issue of the SGD newsletter. The goal of this newsletter is to inform our users about new features in SGD and to foster communication within the yeast community. You can view this [https://wiki.yeastgenome.org/index.php/SGD_Newsletter,_Summer_2023 newsletter] as well as previous newsletters, on our [https://wiki.yeastgenome.org/index.php/SGD_Newsletter_Archives Community Wiki].
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'''About this newsletter:''' <br> This is the Summer 2023 issue of the SGD newsletter. The goal of this newsletter is to inform our users about new features in SGD and to foster communication within the yeast community. You can view this [https://wiki.yeastgenome.org/index.php/SGD_Newsletter,_Summer_2023 newsletter] as well as previous newsletters, on the SGD [https://wiki.yeastgenome.org/index.php/SGD_Newsletter_Archives Community Wiki].
  
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==topic==
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==Biochemical Pathways added to SGD Search==
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[[Image:sgd_maintenanceguy.jpeg |thumb|left|upright=.5]]
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[[Image:pathwaysSearch.png |thumb|left|upright=1.25]]
  
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Thousands of SGD users run their data against SGD data every day and this can put a heavy load on servers. To improve performance, we have invested in dockerizing our full database so that loads can be better distributed in real time. We are currently at the stage of testing the frontend of our software to look for bugs, which we do for every update. The next phase will entail dockerizing and testing the backend, so we can improve our data uploads.  
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Biochemical pathways have been added to SGD search in order to facilitate easy access to metabolic yeast pathway pages at [http://pathway.yeastgenome.org YeastPathways].
  
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We hope to see improved performance for you, our users. If you happen to notice faster speeds or fewer hiccups…we’d be quite glad to hear about it! (A message to the SGD Helpdesk reaches us all.)
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YeastPathways is a database of metabolic pathways and enzymes in the budding yeast ''Saccharomyces cerevisiae''. YeastPathways content is manually curated and maintained by the curation team at SGD, your model organism database for budding yeast. Check it out! 👀 http://yeastgenome.org/search?q=&category=pathway
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<br><br><br><br>
 
  
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==topic==
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Manual curation of pathways is an ongoing process at SGD. We welcome feedback from the research community. Please feel free to [mailto:sgd-helpdesk@lists.stanford.edu contact us] with any questions or comments.
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[[Image:ResearchSpotlight_2022-07-26_at_9.32.28_AM.png|link=https://www.yeastgenome.org/ |thumb|left|upright=.5]]
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</p><p>
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<br />
  
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SGD triages all the papers that come out each week to find those that add value to our database. In the process, we are continually impressed by the quality of the research done in yeast and we decided it was time to bring back the “Research Spotlight” as a post that appears on the SGD home page in the "New and Noteworthy" section.
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==GENETICS Knowledgebase and Database Resources==
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[[Image:GENETICSmodUpdates.png|link=https://www.yeastgenome.org/blog/genetics-knowledgebase-and-database-resources |thumb|left|upright=.75]]
  
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The goal is to highlight interesting new work that either continues an ongoing story, makes a twist in the story we all thought we knew (such as an unexpected side gig for a protein), or offers a new technique or perspective for mining the most value from the yeast model. There are numerous intriguing papers in yeast, including those shedding light on human disease by dissecting the cellular biology in yeast, using our remarkable tools, so as to identify new targets or drugs for humans.
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The [https://academic.oup.com/genetics/issue/224/1 May 2023 issue] of [https://academic.oup.com/genetics GENETICS] features the second annual collection of Model Organism Database articles.  
  
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As the model organism databases move toward forming the Alliance of Genome Resources, which will streamline and integrate our combined data, we expect this power to make useful connections will only grow.
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Scientists from [https://www.alliancegenome.org Alliance of Genome Resources] member groups [https://www.yeastgenome.org SGD], [https://www.alliancegenome.org/members/rgd RGD], [https://www.alliancegenome.org/members/zfin ZFIN], [https://www.alliancegenome.org/members/goc Gene Ontology], and [https://www.xenbase.org/entry/ Xenbase] have provided updates on recent activities and innovations.
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Be sure to browse the issue and get acquainted with these excellent Knowledgebase and Database Resource papers at GENETICS.
 
<br><br>
 
<br><br>
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*SGD https://doi.org/10.1093/genetics/iyac191
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*RGD https://doi.org/10.1093/genetics/iyad042
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*ZFIN https://doi.org/10.1093/genetics/iyad032
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*Gene Ontology (GO) https://doi.org/10.1093/genetics/iyad031
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*Xenbase https://doi.org/10.1093/genetics/iyad018
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</p><p>
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<br />
  
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==Upcoming Yeast Genetics Meeting==
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==SGD designated "Global Core Biodata Resource"==
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[[image:YGM2022.png | link=https://genetics-gsa.org/yeast-2022/|thumb|left|upright=.9]]
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[[Image:FkAzFtQWIAExhDl.jpeg|link=https://www.yeastgenome.org/blog/global-biodata-coalition-selects-sgd-in-first-set-of-global-core-biodata-resources |thumb|left|upright=.75]]
  
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We may have forgotten how to talk to other people ''in person'', but the [https://genetics-gsa.org/yeast-2022/ Yeast Genetics Meeting] is going to give us a chance to practice. The meeting will be held in person for the first time in four years at UCLA, from August 17-21. We hope to see you there!
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We are proud that SGD has been included in the first list of [https://globalbiodata.org/scientific-activities/global-core-biodata-resources/ Global Core Biodata Resources] (GCBRs) announced last December by the [https://globalbiodata.org/ Global Biodata Coalition] (GBC)! This collection of 37 resources comprises deposition databases which archive and preserve primary research data, and knowledgebases, such as SGD, that add value to research data through expert curation and annotation. The list is meant to highlight those data resources whose long term funding and sustainability is critical to life science and biomedical research worldwide.
  
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Of course, it being the COVID era, you can also register to attend virtually, and the cost will not be higher for late registration.  
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GCBRs represent the most crucial resources within the global life science data community. SGD’s selection as a key global data resource recognizes that SGD is essential to the global research endeavor.
  
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For more information regarding the Global Biodata Coalition, including a link to the full list of selected core biodata resources, please see the full press release from the GBC.
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</p><p>
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<br />
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==2D RNA structures from RNAcentral==
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[[Image:RNAcentral.png|link=https://www.yeastgenome.org/blog/2d-rna-structures-from-rnacentral |thumb|right|upright=.4]]
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SGD recently updated our RNA pages to add secondary structures provided by [https://rnacentral.org/ RNAcentral] and generated by [https://github.com/RNAcentral/r2dt R2DT].
  
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A big congratulations to the award recipients who are the [https://genetics-gsa.org/yeast-2022/invited-speakers/ invited speakers] for 2022. Tom Petes is receiving the YGM Lifetime Achievement Award, Trisha Davis is giving the Winge-Lindegren Address, Maya Schuldiner is receiving the Ira Herskowitz Award, and Michael Desai is giving the Lee Hartwell Lecture. Learn more about these researchers and their work at the YGM website.
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Thumbnails and linkouts to RNAcentral via RNAcentral IDs are shown on the [https://www.yeastgenome.org/locus/YNCQ0010W Summary] and Sequence pages. Interactive secondary structure viewers are available on the [https://www.yeastgenome.org/locus/YNCQ0010W/sequence#secondary_structure Sequence] pages.  
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<br><br>
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Take the pages for a spin! For more information about the structures, please see the [https://rnacentral.org/help/secondary-structure Help page] at RNAcentral.
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</p><p>
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</p><p>
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<br />
  
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==SGD collaborates to add new data links (THIS TOPIC NEEDS UPDATING)==
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==CoSMoS.c. - Conserved Sequence Motif in ''Saccharomyces cerevisiae''==
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[[Image:AlphaFoldPrediction.png|thumb|right|upright=.4]]
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[[Image:cosmosc.png|thumb|left|upright=.5]]
  
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On the topic of integration, SGD is happy to integrate new data sets that add value to the database. We have the ability to incorporate these datasets directly from research groups, rather than from publications. Most recently we integrated the [http://www.science.org/doi/10.1126/science.abm4805 AlphaFold] predicted 3D structures for complexes as links on the SGD Interaction and Protein pages. It is now possible to look for your own proteins or complexes of interest and go straight to the predicted structure.  
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The new website [https://shiny-server-dept-yeast-cosmos.apps.cloudapps.unc.edu CoSMoS.c.] - Conserved Sequence Motif in ''Saccharomyces cerevisiae'' - may be of interest to investigators who study protein modifications in budding yeast. The new web-based search algorithm scores conservation of amino acid sequences based on whole-genome sequencing of 1000+ wild and domesticated yeast isolates.  
  
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Another recent example is [https://www.weizmann.ac.il/molgen/AnalogYeast AnalogYeast], a dataset of analogs to yeast proteins in non-fungal organisms predicted by sequence similarity, which was created by the [https://mayaschuldiner.wixsite.com/schuldinerlab Schuldiner lab]. Links have been added to the Resources sections of SGD [https://yeastgenome.org/locus/S000005737/protein#resources Protein] and [https://yeastgenome.org/locus/S000005737/homology#resources Homology] pages.  
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In the [https://www.yeastgenome.org/reference/36933807 recent publication describing the method], Li and Dohlman examined each of the 550 pairs of duplicated genes in ''S. cerevisiae'', integrating 38,000+ documented post-translational modifications (PTMs), and 30,000+ reported interactions between protein kinases and substrates (all obtained from [https://www.yeastgenome.org SGD]!). More than 3,500 instances were identified where only one of two paralogous proteins undergoes a PTM despite having retained the same amino acid residue in both. Li and Dohlman found that the most common modifications – phosphorylation, ubiquitylation and acylation, but not N-glycosylation – occur in regions of high sequence conservation. The analysis indicates that differences in PTMs may be an important source of protein neo- or sub-functionalization, and that such differences likely account for the retention of closely related enzymes throughout evolution.
  
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We are open to more of this collaboration and would be glad to hear from community members who think they have data useful to other researchers. Get in touch!
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You can find links to [https://shiny-server-dept-yeast-cosmos.apps.cloudapps.unc.edu CoSMoS.c.] at the bottom of your favorite protein page at SGD, in the Resources section under Post-translational Modifications.
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</p><p>
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<br />
  
 
==microPublications - latest yeast papers==
 
==microPublications - latest yeast papers==
Line 59: Line 82:
  
 
All yeast microPublications can be found in [https://www.yeastgenome.org/search?category=reference&journal=microPublication.%20Biology&page=0&q= SGD].
 
All yeast microPublications can be found in [https://www.yeastgenome.org/search?category=reference&journal=microPublication.%20Biology&page=0&q= SGD].
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</p><p>
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<br />
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==Alliance of Genome Resources - Releases 5.3 & 5.4==
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[[Image:alliance_logo.png|link=https://www.alliancegenome.org/ |thumb|left|upright=.725]]
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The [https://www.alliancegenome.org/ Alliance of Genome Resources], a collaborative effort from SGD and other model organism databases (MOD), released version 5.3 last October and [https://www.alliancegenome.org/release-notes version 5.4] this past April.
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'''Version 5.3''' saw the addition of ''Xenopus'' data from Xenbase. These amphibians are an important tetrapod model, spanning the evolutionary gap between the mammalian (human, mouse, and rat) and zebrafish data already included in the Alliance. ''Xenopus'' have long been used in developmental and cell biology, and two species are widely studied. The African clawed frog, ''X. laevis'' is an allotetraploid (2n = 36) of hybrid origin. The resulting ''X. laevis'' genome has a set of ‘long’ and ‘short’ chromosomes and gene symbols are therefore appended with ‘.L’ or ‘.S’ denoting on which chromosome pair they reside. The second ''Xenopus'' species, the Western clawed frog ''X. tropicalis'', is a conventional diploid (2n=20), and is increasingly used in human disease modeling.
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Data for both ''Xenopus'' species are organized on individual gene pages that feature data such as gene descriptions, orthology to human and other species, disease associations for orthologs, an expression ribbon view, and a Sequence Feature Viewer.
  
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==Alliance of Genome Resources - Release 5.4==
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'''Version 5.4''' provides new Alliance SimpleMine and Facebook URLs:
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[[Image:alliance_logo.png|link=https://www.alliancegenome.org/ |thumb|left|upright=.5]]
 
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The [https://www.alliancegenome.org/ Alliance of Genome Resources], a collaborative effort from SGD and other model organism databases (MOD), released [https://www.alliancegenome.org/release-notes version 5.4] this past April.
 
  
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*SimpleMine, which allows you to perform basic batch searches of Alliance data, has a new URL: https://www.alliancegenome.org/agr_simplemine.cgi
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*SimpleMine allows basic batch searches of Alliance data: https://www.alliancegenome.org/agr_simplemine.cgi
  
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*For fans of Facebook, The Alliance of Genome Resources has a new Facebook page:
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*The Alliance of Genome Resources has a new Facebook page: https://www.facebook.com/AllianceOfGenomeResources
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https://www.facebook.com/AllianceOfGenomeResources
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</p><p>
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<br />
  
 
==Upcoming Conferences and Courses==
 
==Upcoming Conferences and Courses==

Latest revision as of 14:18, 22 June 2023

About this newsletter:
This is the Summer 2023 issue of the SGD newsletter. The goal of this newsletter is to inform our users about new features in SGD and to foster communication within the yeast community. You can view this newsletter as well as previous newsletters, on the SGD Community Wiki.

Biochemical Pathways added to SGD Search

pathwaysSearch.png

Biochemical pathways have been added to SGD search in order to facilitate easy access to metabolic yeast pathway pages at YeastPathways.

YeastPathways is a database of metabolic pathways and enzymes in the budding yeast Saccharomyces cerevisiae. YeastPathways content is manually curated and maintained by the curation team at SGD, your model organism database for budding yeast. Check it out! 👀 http://yeastgenome.org/search?q=&category=pathway

Manual curation of pathways is an ongoing process at SGD. We welcome feedback from the research community. Please feel free to contact us with any questions or comments.


GENETICS Knowledgebase and Database Resources

GENETICSmodUpdates.png

The May 2023 issue of GENETICS features the second annual collection of Model Organism Database articles.

Scientists from Alliance of Genome Resources member groups SGD, RGD, ZFIN, Gene Ontology, and Xenbase have provided updates on recent activities and innovations.

Be sure to browse the issue and get acquainted with these excellent Knowledgebase and Database Resource papers at GENETICS.


SGD designated "Global Core Biodata Resource"

FkAzFtQWIAExhDl.jpeg

We are proud that SGD has been included in the first list of Global Core Biodata Resources (GCBRs) announced last December by the Global Biodata Coalition (GBC)! This collection of 37 resources comprises deposition databases which archive and preserve primary research data, and knowledgebases, such as SGD, that add value to research data through expert curation and annotation. The list is meant to highlight those data resources whose long term funding and sustainability is critical to life science and biomedical research worldwide.

GCBRs represent the most crucial resources within the global life science data community. SGD’s selection as a key global data resource recognizes that SGD is essential to the global research endeavor.

For more information regarding the Global Biodata Coalition, including a link to the full list of selected core biodata resources, please see the full press release from the GBC.


2D RNA structures from RNAcentral

RNAcentral.png

SGD recently updated our RNA pages to add secondary structures provided by RNAcentral and generated by R2DT.

Thumbnails and linkouts to RNAcentral via RNAcentral IDs are shown on the Summary and Sequence pages. Interactive secondary structure viewers are available on the Sequence pages.

Take the pages for a spin! For more information about the structures, please see the Help page at RNAcentral.



CoSMoS.c. - Conserved Sequence Motif in Saccharomyces cerevisiae

cosmosc.png

The new website CoSMoS.c. - Conserved Sequence Motif in Saccharomyces cerevisiae - may be of interest to investigators who study protein modifications in budding yeast. The new web-based search algorithm scores conservation of amino acid sequences based on whole-genome sequencing of 1000+ wild and domesticated yeast isolates.

In the recent publication describing the method, Li and Dohlman examined each of the 550 pairs of duplicated genes in S. cerevisiae, integrating 38,000+ documented post-translational modifications (PTMs), and 30,000+ reported interactions between protein kinases and substrates (all obtained from SGD!). More than 3,500 instances were identified where only one of two paralogous proteins undergoes a PTM despite having retained the same amino acid residue in both. Li and Dohlman found that the most common modifications – phosphorylation, ubiquitylation and acylation, but not N-glycosylation – occur in regions of high sequence conservation. The analysis indicates that differences in PTMs may be an important source of protein neo- or sub-functionalization, and that such differences likely account for the retention of closely related enzymes throughout evolution.

You can find links to CoSMoS.c. at the bottom of your favorite protein page at SGD, in the Resources section under Post-translational Modifications.


microPublications - latest yeast papers

MicroPub.png

​microPublication Biology is part of the emerging genre of rapidly-published research communications. We are seeing a strong set of microPublications come through the database and are glad for this venue to publish brief, novel findings, negative and/or reproduced results, and results which may initially lack a broader scientific narrative. Each article is peer-reviewed, assigned a DOI, and indexed through PubMed and PubMedCentral.

Consider microPubublications when you have a result that doesn't necessarily fit into a larger story, but will be of value to others.

Latest yeast microPublications:

  • Daraghmi MM, et al. (2023) Macro-ER-phagy receptors Atg39p and Atg40p confer resistance to aminoglycoside hygromycin B in S. cerevisiae. MicroPubl Biol 2023
  • Domeni Zali G and Moriel-Carretero M (2023) Auxin alone provokes retention of ASH1 mRNA in Saccharomyces cerevisiae mother cells. MicroPubl Biol 2023
  • Hiestand L, et al. (2023) Chemical Genetics Screen of EVP4593 Sensitivity in Budding Yeast Identifies Effects on Mitochondrial Structure and Function. MicroPubl Biol 2023
  • Liu L, et al. (2023) A role for ion homeostasis in yeast ionic liquid tolerance. MicroPubl Biol 2023
  • Longan ER, et al. (2023) ADATscan - A flexible tool for scanning exomes for wobble inosine-dependent codons reveals a neurological bias for genes enriched in such codons in humans and mice. MicroPubl Biol 2023
  • Miles S, et al. (2023) BY4741 cannot enter quiescence from rich medium. MicroPubl Biol 2023
  • Moresi NG, et al. (2023) Caffeine-tolerant mutations selected through an at-home yeast experimental evolution teaching lab. MicroPubl Biol 2023
  • Shortt C, et al. (2023) A simple and accessible CRISPR genome editing laboratory exercise using yeast. MicroPubl Biol 2023

All yeast microPublications can be found in SGD.


Alliance of Genome Resources - Releases 5.3 & 5.4

alliance logo.png

The Alliance of Genome Resources, a collaborative effort from SGD and other model organism databases (MOD), released version 5.3 last October and version 5.4 this past April.

Version 5.3 saw the addition of Xenopus data from Xenbase. These amphibians are an important tetrapod model, spanning the evolutionary gap between the mammalian (human, mouse, and rat) and zebrafish data already included in the Alliance. Xenopus have long been used in developmental and cell biology, and two species are widely studied. The African clawed frog, X. laevis is an allotetraploid (2n = 36) of hybrid origin. The resulting X. laevis genome has a set of ‘long’ and ‘short’ chromosomes and gene symbols are therefore appended with ‘.L’ or ‘.S’ denoting on which chromosome pair they reside. The second Xenopus species, the Western clawed frog X. tropicalis, is a conventional diploid (2n=20), and is increasingly used in human disease modeling.

Data for both Xenopus species are organized on individual gene pages that feature data such as gene descriptions, orthology to human and other species, disease associations for orthologs, an expression ribbon view, and a Sequence Feature Viewer.

Version 5.4 provides new Alliance SimpleMine and Facebook URLs:


Upcoming Conferences and Courses

  • Yeast Genetics & Genomics - modern and intensive laboratory course that teaches students the full repertoire of genetic and genomic approaches needed to dissect complex problems using the yeast Saccharomyces cerevisiae
    • Cold Spring Harbor Laboratory, NY
    • July 26 - August 15, 2023
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