Difference between revisions of "YKR010C"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YKR010C YKR010C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001718 YKR010C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TOF2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TOF2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XI:460882..458567
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|nowrap| Chr XI:461239..458924
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001718
 
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'''Description of {{PAGENAME}}:''' Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1<ref name='S000075100'>Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 {{SGDpaper|S000075100}} PMID 14576278</ref><ref name='S000070038'>Zuniga S, et al. (1999) Deletion of 24 open reading frames from chromosome XI from Saccharomyces cerevisiae and phenotypic analysis of the deletants. Gene 233(1-2):141-50 {{SGDpaper|S000070038}} PMID 10375630</ref><ref name='S000042267'>Park H and Sternglanz R (1999) Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae. Yeast 15(1):35-41
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'''Description of YKR010C:''' Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site<ref name='S000126882'>Geil C, et al. (2008) A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr Biol 18(13):1001-5 {{SGDpaper|S000126882}} PMID 18595708</ref><ref name='S000119372'>Huang J, et al. (2006) Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev 20(20):2887-901 {{SGDpaper|S000119372}} PMID 17043313</ref><ref name='S000129985'>Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35 {{SGDpaper|S000129985}} PMID 19362534</ref><ref name='S000128034'>Waples WG, et al. (2009) Putting the Brake on FEAR: Tof2 Promotes the Biphasic Release of Cdc14 Phosphatase during Mitotic Exit. Mol Biol Cell 20(1):245-55
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  {{SGDpaper|S000042267}} PMID 10028183</ref>
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  {{SGDpaper|S000128034}} PMID 18923139</ref>
 
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J Biol Chem 278(5):3265-74</ref>
 
J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YKR010C
Gene name TOF2
Aliases
Feature type ORF, Verified
Coordinates Chr XI:461239..458924
Primary SGDID S000001718


Description of YKR010C: Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site[1][2][3][4]




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References

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  1. ↑ Geil C, et al. (2008) A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr Biol 18(13):1001-5 SGD PMID 18595708
  2. ↑ Huang J, et al. (2006) Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev 20(20):2887-901 SGD PMID 17043313
  3. ↑ Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35 SGD PMID 19362534
  4. ↑ Waples WG, et al. (2009) Putting the Brake on FEAR: Tof2 Promotes the Biphasic Release of Cdc14 Phosphatase during Mitotic Exit. Mol Biol Cell 20(1):245-55 SGD PMID 18923139

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