Difference between revisions of "YDR081C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR081C YDR081C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002488 YDR081C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PDC2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PDC2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:610078..607301
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|nowrap| Chr IV:610081..607304
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002488
 
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'''Description of {{PAGENAME}}:''' Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes<ref name='S000055265'>Kaiser B, et al. (1999) Identification of a gene encoding the pyruvate decarboxylase gene regulator CaPdc2p from Candida albicans. Yeast 15(7):585-91 {{SGDpaper|S000055265}} PMID 10341421</ref><ref name='S000046055'>Hohmann S and Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385(2):201-19 {{SGDpaper|S000046055}} PMID 9655908</ref><ref name='S000042760'>Velmurugan S, et al. (1997) Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics 145(3):587-94
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'''Description of YDR081C:''' Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions<ref name='S000050008'>Hohmann S (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):657-66 {{SGDpaper|S000050008}} PMID 8264540</ref><ref name='S000046055'>Hohmann S and Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385(2):201-19 {{SGDpaper|S000046055}} PMID 9655908</ref><ref name='S000117265'>Mojzita D and Hohmann S (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61 {{SGDpaper|S000117265}} PMID 16850348</ref><ref name='S000128371'>Nosaka K, et al. (2008) Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett 582(29):3991-6 {{SGDpaper|S000128371}} PMID 19013460</ref><ref name='S000148779'>Nosaka K, et al. (2012) Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation.LID - 10.1111/j.1574-6968.2012.02543.x [doi] FEMS Microbiol Lett () {{SGDpaper|S000148779}} PMID 22404710</ref><ref name='S000147201'>Raghuram V, et al. (1994) PDC2, a yeast gene essential for synthesis of pyruvate decarboxylase, encodes a novel transcription factor J Genet 73():17-32 {{SGDpaper|S000147201}} PMID </ref><ref name='S000042760'>Velmurugan S, et al. (1997) Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics 145(3):587-94
 
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==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 13:05, 26 March 2012

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Systematic name YDR081C
Gene name PDC2
Aliases
Feature type ORF, Verified
Coordinates Chr IV:610081..607304
Primary SGDID S000002488


Description of YDR081C: Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions[1][2][3][4][5][6][7]




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References

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  1. ↑ Hohmann S (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):657-66 SGD PMID 8264540
  2. ↑ Hohmann S and Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385(2):201-19 SGD PMID 9655908
  3. ↑ Mojzita D and Hohmann S (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61 SGD PMID 16850348
  4. ↑ Nosaka K, et al. (2008) Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett 582(29):3991-6 SGD PMID 19013460
  5. ↑ Nosaka K, et al. (2012) Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation.LID - 10.1111/j.1574-6968.2012.02543.x [doi] FEMS Microbiol Lett () SGD PMID 22404710
  6. ↑ Raghuram V, et al. (1994) PDC2, a yeast gene essential for synthesis of pyruvate decarboxylase, encodes a novel transcription factor J Genet 73():17-32 SGD PMID
  7. ↑ Velmurugan S, et al. (1997) Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics 145(3):587-94 SGD PMID 9055069

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