Difference between revisions of "YJR069C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003830 YJR069C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HAM1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HAM1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr X: | + | |nowrap| Chr X:569399..568806 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003830 | ||
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| − | '''Description of | + | '''Description of YJR069C:''' Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine<ref name='S000119608'>Burgis NE and Cunningham RP (2007) Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem 282(6):3531-8 {{SGDpaper|S000119608}} PMID 17090528</ref><ref name='S000149274'>Davies O, et al. (2012) Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism. BMB Rep 45(4):259-64 {{SGDpaper|S000149274}} PMID 22531138</ref><ref name='S000056098'>Noskov VN, et al. (1996) HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. Yeast 12(1):17-29 {{SGDpaper|S000056098}} PMID 8789257</ref><ref name='S000148315'>Pang B, et al. (2012) Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proc Natl Acad Sci U S A () {{SGDpaper|S000148315}} PMID 22308425</ref><ref name='S000124206'>Takayama S, et al. (2007) Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Curr Genet 52(5-6):203-11 |
| − | {{SGDpaper| | + | {{SGDpaper|S000124206}} PMID 17899088</ref> |
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 14:05, 7 May 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YJR069C |
| Gene name | HAM1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:569399..568806 |
| Primary SGDID | S000003830 |
Description of YJR069C: Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine[1][2][3][4][5]
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Contents
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References
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- ↑ Burgis NE and Cunningham RP (2007) Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem 282(6):3531-8 SGD PMID 17090528
- ↑ Davies O, et al. (2012) Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism. BMB Rep 45(4):259-64 SGD PMID 22531138
- ↑ Noskov VN, et al. (1996) HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. Yeast 12(1):17-29 SGD PMID 8789257
- ↑ Pang B, et al. (2012) Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proc Natl Acad Sci U S A () SGD PMID 22308425
- ↑ Takayama S, et al. (2007) Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Curr Genet 52(5-6):203-11 SGD PMID 17899088
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