Difference between revisions of "YFR003C"
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| − | '''Description of YFR003C:''' | + | '''Description of YFR003C:''' Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance<ref name='S000125078'>Bharucha JP, et al. (2008) Ypi1, a Positive Regulator of Nuclear Protein Phosphatase Type 1 Activity in Saccharomyces cerevisiae. Mol Biol Cell 19(3):1032-45 {{SGDpaper|S000125078}} PMID 18172024</ref><ref name='S000074628'>Garcia-Gimeno MA, et al. (2003) Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. J Biol Chem 278(48):47744-52 {{SGDpaper|S000074628}} PMID 14506263</ref><ref name='S000148575'>Marquina M, et al. (2012) Modulation of Yeast Alkaline Cation Tolerance by Ypi1 Requires Calcineurin. Genetics () |
{{SGDpaper|S000148575}} PMID 22367039</ref> | {{SGDpaper|S000148575}} PMID 22367039</ref> | ||
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Latest revision as of 13:05, 3 May 2012
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| Systematic name | YFR003C |
| Gene name | YPI1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:153124..152657 |
| Primary SGDID | S000001899 |
Description of YFR003C: Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance[1][2][3]
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References
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- ↑ Bharucha JP, et al. (2008) Ypi1, a Positive Regulator of Nuclear Protein Phosphatase Type 1 Activity in Saccharomyces cerevisiae. Mol Biol Cell 19(3):1032-45 SGD PMID 18172024
- ↑ Garcia-Gimeno MA, et al. (2003) Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. J Biol Chem 278(48):47744-52 SGD PMID 14506263
- ↑ Marquina M, et al. (2012) Modulation of Yeast Alkaline Cation Tolerance by Ypi1 Requires Calcineurin. Genetics () SGD PMID 22367039
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