Difference between revisions of "YER019W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000821 YER019W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ISC1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ISC1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr V: | + | |nowrap| Chr V:192797..194230 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000821 | ||
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| − | '''Description of | + | '''Description of YER019W:''' Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance<ref name='S000070403'>Betz C, et al. (2002) ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur J Biochem 269(16):4033-9 {{SGDpaper|S000070403}} PMID 12180980</ref><ref name='S000072039'>Okamoto Y, et al. (2002) Structural requirements for selective binding of ISC1 to anionic phospholipids. J Biol Chem 277(48):46470-7 {{SGDpaper|S000072039}} PMID 12244059</ref><ref name='S000059300'>Sawai H, et al. (2000) Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem 275(50):39793-8 |
{{SGDpaper|S000059300}} PMID 11006294</ref> | {{SGDpaper|S000059300}} PMID 11006294</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YER019W |
| Gene name | ISC1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:192797..194230 |
| Primary SGDID | S000000821 |
Description of YER019W: Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance[1][2][3]
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References
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- ↑ Betz C, et al. (2002) ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur J Biochem 269(16):4033-9 SGD PMID 12180980
- ↑ Okamoto Y, et al. (2002) Structural requirements for selective binding of ISC1 to anionic phospholipids. J Biol Chem 277(48):46470-7 SGD PMID 12244059
- ↑ Sawai H, et al. (2000) Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem 275(50):39793-8 SGD PMID 11006294
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