Difference between revisions of "YDR005C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR005C YDR005C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002412 YDR005C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MAF1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MAF1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:458100..456833
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|nowrap| Chr IV:458103..456836
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002412
 
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'''Description of {{PAGENAME}}:''' Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB<ref name='S000047345'>Boguta M, et al. (1997) Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae. Gene 185(2):291-6
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'''Description of YDR005C:''' Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions<ref name='S000047345'>Boguta M, et al. (1997) Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae. Gene 185(2):291-6 {{SGDpaper|S000047345}} PMID 9055829</ref><ref name='S000080103'>Desai N, et al. (2005) Two steps in Maf1-dependent repression of transcription by RNA polymerase III. J Biol Chem 280(8):6455-62 {{SGDpaper|S000080103}} PMID 15590667</ref><ref name='S000129666'>Lee J, et al. (2009) Regulation of RNA Polymerase III Transcription Involves SCH9-dependent and SCH9-independent Branches of the Target of Rapamycin (TOR) Pathway. J Biol Chem 284(19):12604-8 {{SGDpaper|S000129666}} PMID 19299514</ref><ref name='S000116307'>Oficjalska-Pham D, et al. (2006) General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1. Mol Cell 22(5):623-32 {{SGDpaper|S000116307}} PMID 16762835</ref><ref name='S000061185'>Pluta K, et al. (2001) Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol 21(15):5031-40 {{SGDpaper|S000061185}} PMID 11438659</ref><ref name='S000126253'>Towpik J, et al. (2008) Derepression of RNA Polymerase III Transcription by Phosphorylation and Nuclear Export of Its Negative Regulator, Maf1. J Biol Chem 283(25):17168-74 {{SGDpaper|S000126253}} PMID 18445601</ref><ref name='S000072839'>Upadhya R, et al. (2002) Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. Mol Cell 10(6):1489-94 {{SGDpaper|S000072839}} PMID 12504022</ref><ref name='S000138857'>Vannini A, et al. (2010) Molecular basis of RNA polymerase III transcription repression by Maf1. Cell 143(1):59-70 {{SGDpaper|S000138857}} PMID 20887893</ref><ref name='S000135147'>Wei Y, et al. (2009) Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J 28(15):2220-30
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J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YDR005C
Gene name MAF1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:458103..456836
Primary SGDID S000002412


Description of YDR005C: Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions[1][2][3][4][5][6][7][8][9]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in phosphorus limited chemostat cultures versus phosphorus excess. [10] [11]




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References

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  1. ↑ Boguta M, et al. (1997) Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae. Gene 185(2):291-6 SGD PMID 9055829
  2. ↑ Desai N, et al. (2005) Two steps in Maf1-dependent repression of transcription by RNA polymerase III. J Biol Chem 280(8):6455-62 SGD PMID 15590667
  3. ↑ Lee J, et al. (2009) Regulation of RNA Polymerase III Transcription Involves SCH9-dependent and SCH9-independent Branches of the Target of Rapamycin (TOR) Pathway. J Biol Chem 284(19):12604-8 SGD PMID 19299514
  4. ↑ Oficjalska-Pham D, et al. (2006) General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1. Mol Cell 22(5):623-32 SGD PMID 16762835
  5. ↑ Pluta K, et al. (2001) Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol 21(15):5031-40 SGD PMID 11438659
  6. ↑ Towpik J, et al. (2008) Derepression of RNA Polymerase III Transcription by Phosphorylation and Nuclear Export of Its Negative Regulator, Maf1. J Biol Chem 283(25):17168-74 SGD PMID 18445601
  7. ↑ Upadhya R, et al. (2002) Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. Mol Cell 10(6):1489-94 SGD PMID 12504022
  8. ↑ Vannini A, et al. (2010) Molecular basis of RNA polymerase III transcription repression by Maf1. Cell 143(1):59-70 SGD PMID 20887893
  9. ↑ Wei Y, et al. (2009) Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J 28(15):2220-30 SGD PMID 19574957
  10. ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  11. ↑ submitted by Viktor Boer on 2003-07-25

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