Difference between revisions of "YDR121W"
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| − | '''Description of YDR121W:''' | + | '''Description of YDR121W:''' Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization<ref name='S000141383'>Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 {{SGDpaper|S000141383}} PMID 21124948</ref><ref name='S000122597'>Dang W, et al. (2007) The Dpb4 Subunit of ISW2 Is Anchored to Extranucleosomal DNA. J Biol Chem 282(27):19418-25 {{SGDpaper|S000122597}} PMID 17491017</ref><ref name='S000050160'>Dua R, et al. (2000) Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon. J Biol Chem 275(37):28816-25 {{SGDpaper|S000050160}} PMID 10878005</ref><ref name='S000075426'>Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 {{SGDpaper|S000075426}} PMID 14673157</ref><ref name='S000054633'>Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 {{SGDpaper|S000054633}} PMID 10801849</ref><ref name='S000056444'>Ohya T, et al. (2000) Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae. Nucleic Acids Res 28(20):3846-52 |
{{SGDpaper|S000056444}} PMID 11024162</ref> | {{SGDpaper|S000056444}} PMID 11024162</ref> | ||
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Latest revision as of 13:05, 1 October 2012
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| Systematic name | YDR121W |
| Gene name | DPB4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:693585..694175 |
| Primary SGDID | S000002528 |
Description of YDR121W: Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization[1][2][3][4][5][6]
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References
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- ↑ Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 SGD PMID 21124948
- ↑ Dang W, et al. (2007) The Dpb4 Subunit of ISW2 Is Anchored to Extranucleosomal DNA. J Biol Chem 282(27):19418-25 SGD PMID 17491017
- ↑ Dua R, et al. (2000) Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon. J Biol Chem 275(37):28816-25 SGD PMID 10878005
- ↑ Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 SGD PMID 14673157
- ↑ Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 SGD PMID 10801849
- ↑ Ohya T, et al. (2000) Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae. Nucleic Acids Res 28(20):3846-52 SGD PMID 11024162
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