Difference between revisions of "YMR243C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004856 YMR243C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ZRC1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ZRC1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XIII: | + | |nowrap| Chr XIII:756166..754838 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004856 | ||
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| − | '''Description of | + | '''Description of YMR243C:''' Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain<ref name='S000050176'>Li L and Kaplan J (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7 {{SGDpaper|S000050176}} PMID 9712830</ref><ref name='S000041386'>MacDiarmid CW, et al. (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. EMBO J 19(12):2845-55 {{SGDpaper|S000041386}} PMID 10856230</ref><ref name='S000073064'>MacDiarmid CW, et al. (2003) Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock. J Biol Chem 278(17):15065-72 {{SGDpaper|S000073064}} PMID 12556516</ref><ref name='S000148519'>Tuschl K, et al. (2012) Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10, a Manganese Transporter in Man. Am J Hum Genet () |
| − | {{SGDpaper| | + | {{SGDpaper|S000148519}} PMID 22341972</ref> |
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 13:05, 13 March 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YMR243C |
| Gene name | ZRC1 |
| Aliases | OSR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:756166..754838 |
| Primary SGDID | S000004856 |
Description of YMR243C: Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain[1][2][3][4]
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References
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- ↑ Li L and Kaplan J (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7 SGD PMID 9712830
- ↑ MacDiarmid CW, et al. (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. EMBO J 19(12):2845-55 SGD PMID 10856230
- ↑ MacDiarmid CW, et al. (2003) Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock. J Biol Chem 278(17):15065-72 SGD PMID 12556516
- ↑ Tuschl K, et al. (2012) Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10, a Manganese Transporter in Man. Am J Hum Genet () SGD PMID 22341972
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