Difference between revisions of "YLR450W"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YLR450W YLR450W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004442 YLR450W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HMG2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HMG2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XII:1032624..1035761
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|nowrap| Chr XII:1032627..1035764
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004442
 
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'''Description of {{PAGENAME}}:''' One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks<ref name='S000055806'>Koning AJ, et al. (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89 {{SGDpaper|S000055806}} PMID 8744950</ref><ref name='S000050136'>Wright R, et al. (1988) Increased amounts of HMG-CoA reductase induce &quot;karmellae&quot;: a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14 {{SGDpaper|S000050136}} PMID 3292536</ref><ref name='S000048924'>Basson ME, et al. (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7 {{SGDpaper|S000048924}} PMID 3526336</ref><ref name='S000039432'>Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30
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'''Description of YLR450W:''' One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks<ref name='S000048924'>Basson ME, et al. (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7 {{SGDpaper|S000048924}} PMID 3526336</ref><ref name='S000055806'>Koning AJ, et al. (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89 {{SGDpaper|S000055806}} PMID 8744950</ref><ref name='S000039432'>Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 {{SGDpaper|S000039432}} PMID 7791530</ref><ref name='S000050136'>Wright R, et al. (1988) Increased amounts of HMG-CoA reductase induce karmellae: a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14
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  {{SGDpaper|S000039432}} PMID 7791530</ref>
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  {{SGDpaper|S000050136}} PMID 3292536</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 06:45, 23 January 2012

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Systematic name YLR450W
Gene name HMG2
Aliases
Feature type ORF, Verified
Coordinates Chr XII:1032627..1035764
Primary SGDID S000004442


Description of YLR450W: One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks[1][2][3][4]




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References

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  1. ↑ Basson ME, et al. (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7 SGD PMID 3526336
  2. ↑ Koning AJ, et al. (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89 SGD PMID 8744950
  3. ↑ Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 SGD PMID 7791530
  4. ↑ Wright R, et al. (1988) Increased amounts of HMG-CoA reductase induce karmellae: a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14 SGD PMID 3292536

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