Difference between revisions of "YGR184C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGR184C YGR184C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003416 YGR184C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''UBR1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''UBR1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr VII:865758..859906
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|nowrap| Chr VII:865753..859901
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003416
 
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'''Description of {{PAGENAME}}:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30():405-39 {{SGDpaper|S000058010}} PMID 8982460</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5
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'''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000044765'>Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 {{SGDpaper|S000044765}} PMID 9427760</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000126742'>Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 {{SGDpaper|S000126742}} PMID 18566452</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000132192'>Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50
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  {{SGDpaper|S000040629}} PMID 1651502</ref>
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  {{SGDpaper|S000132192}} PMID 16311597</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 06:45, 23 January 2012

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Systematic name YGR184C
Gene name UBR1
Aliases PTR1
Feature type ORF, Verified
Coordinates Chr VII:865753..859901
Primary SGDID S000003416


Description of YGR184C: E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)[1][2][3][4][5][6]




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References

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  1. ↑ Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 SGD PMID 2209542
  2. ↑ Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 SGD PMID 9427760
  3. ↑ Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 SGD PMID 1651502
  4. ↑ Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 SGD PMID 18566452
  5. ↑ Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 SGD PMID 10688918
  6. ↑ Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 SGD PMID 16311597

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