Difference between revisions of "YBR136W"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBR136W YBR136W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000340 YBR136W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MEC1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MEC1 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''ESR1, SAD3''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''ESR1, RAD31, SAD3''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr II:505662..512768
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|nowrap| Chr II:505668..512774
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|-
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000340
 
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'''Description of {{PAGENAME}}:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination<ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 {{SGDpaper|S000054274}} PMID 7926756</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20
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'''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres<ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000148240'>Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () {{SGDpaper|S000148240}} PMID 22289863</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000150401'>Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () {{SGDpaper|S000150401}} PMID 22842922</ref><ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65
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  {{SGDpaper|S000039357}} PMID 10511543</ref>
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  {{SGDpaper|S000054274}} PMID 7926756</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
{{CommentaryHelp}}
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 13:05, 16 August 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YBR136W
Gene name MEC1
Aliases ESR1, RAD31, SAD3
Feature type ORF, Verified
Coordinates Chr II:505668..512774
Primary SGDID S000000340


Description of YBR136W: Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres[1][2][3][4][5][6][7][8]




</protect>

Community Commentary

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References

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  1. ↑ Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 SGD PMID 8939848
  2. ↑ Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 SGD PMID 10511543
  3. ↑ Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () SGD PMID 22289863
  4. ↑ Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 SGD PMID 8065923
  5. ↑ Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 SGD PMID 8744945
  6. ↑ Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
  7. ↑ Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 SGD PMID 9610409
  8. ↑ Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 SGD PMID 7926756

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