Difference between revisions of "YML010W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004470 YML010W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SPT5 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SPT5 '' | ||
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| − | '''Description of YML010W:''' | + | '''Description of YML010W:''' Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair<ref name='S000146227'>Anderson SJ, et al. (2011) The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively. J Biol Chem 286(21):18816-24 {{SGDpaper|S000146227}} PMID 21467039</ref><ref name='S000132618'>Ding B, et al. (2010) The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair. J Biol Chem 285(8):5317-26 {{SGDpaper|S000132618}} PMID 20042611</ref><ref name='S000146926'>Lepore N and Lafontaine DL (2011) A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast. PLoS One 6(9):e24962 {{SGDpaper|S000146926}} PMID 21949810</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000130855'>Liu Y, et al. (2009) Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol 29(17):4852-63 {{SGDpaper|S000130855}} PMID 19581288</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 {{SGDpaper|S000120445}} PMID 16908835</ref><ref name='S000135750'>Shen Z, et al. (2010) Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud. Genes Dev 24(17):1914-26 {{SGDpaper|S000135750}} PMID 20713510</ref><ref name='S000129944'>Zhou K, et al. (2009) Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5. Proc Natl Acad Sci U S A 106(17):6956-61 |
| − | {{SGDpaper| | + | {{SGDpaper|S000129944}} PMID 19365074</ref> |
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Latest revision as of 13:05, 24 February 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YML010W |
| Gene name | SPT5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:247677..250868 |
| Primary SGDID | S000004470 |
Description of YML010W: Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair[1][2][3][4][5][6][7][8][9]
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References
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- ↑ Anderson SJ, et al. (2011) The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively. J Biol Chem 286(21):18816-24 SGD PMID 21467039
- ↑ Ding B, et al. (2010) The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair. J Biol Chem 285(8):5317-26 SGD PMID 20042611
- ↑ Lepore N and Lafontaine DL (2011) A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast. PLoS One 6(9):e24962 SGD PMID 21949810
- ↑ Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 SGD PMID 12556496
- ↑ Liu Y, et al. (2009) Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol 29(17):4852-63 SGD PMID 19581288
- ↑ Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 SGD PMID 12554661
- ↑ Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 SGD PMID 16908835
- ↑ Shen Z, et al. (2010) Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud. Genes Dev 24(17):1914-26 SGD PMID 20713510
- ↑ Zhou K, et al. (2009) Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5. Proc Natl Acad Sci U S A 106(17):6956-61 SGD PMID 19365074
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