Difference between revisions of "YDR244W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002652 YDR244W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PEX5 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PEX5 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:950563..952401 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002652 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002652 | ||
Latest revision as of 06:45, 23 January 2012
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| Systematic name | YDR244W |
| Gene name | PEX5 |
| Aliases | PAS10 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:950563..952401 |
| Primary SGDID | S000002652 |
Description of YDR244W: Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions[1][2][3][4]
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Community Commentary
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Protein Details
Other Protein Details
Other Topic: Homology
Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [5] [6]
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References
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- ↑ Brocard C, et al. (1994) The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL. Biochem Biophys Res Commun 204(3):1016-22 SGD PMID 7980572
- ↑ Erdmann R and Blobel G (1996) Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor. J Cell Biol 135(1):111-21 SGD PMID 8858167
- ↑ Klein AT, et al. (2002) Saccharomyces cerevisiae acyl-CoA oxidase follows a novel, non-PTS1, import pathway into peroxisomes that is dependent on Pex5p. J Biol Chem 277(28):25011-9 SGD PMID 11967269
- ↑ Van der Leij I, et al. (1993) PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 90(24):11782-6 SGD PMID 8265627
- ↑ Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
- ↑ submitted by Toni Gabaldon on 2006-04-12
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