Difference between revisions of "YOL025W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005385 YOL025W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''LAG2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''LAG2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XV: | + | |nowrap| Chr XV:274957..276939 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005385 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005385 | ||
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| − | '''Description of YOL025W:''' Protein | + | '''Description of YOL025W:''' Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 {{SGDpaper|S000131589}} PMID 19763088</ref><ref name='S000132362'>Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56 |
{{SGDpaper|S000132362}} PMID 19942853</ref> | {{SGDpaper|S000132362}} PMID 19942853</ref> | ||
<br> | <br> | ||
Latest revision as of 06:45, 23 January 2012
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| Systematic name | YOL025W |
| Gene name | LAG2 |
| Aliases | ECM36 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:274957..276939 |
| Primary SGDID | S000005385 |
Description of YOL025W: Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1[1][2][3]
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References
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- ↑ Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 SGD PMID 8760941
- ↑ Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 SGD PMID 19763088
- ↑ Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56 SGD PMID 19942853
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