Difference between revisions of "YCL026C-A"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000589 YCL026C-A] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FRM2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FRM2 '' | ||
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| − | '''Description of YCL026C-A:''' | + | '''Description of YCL026C-A:''' Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin<ref name='S000120120'>Azevedo D, et al. (2007) The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain. FEBS Lett 581(2):187-195 {{SGDpaper|S000120120}} PMID 17187783</ref><ref name='S000149799'>Bang SY, et al. (2012) Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Biochem Biophys Res Commun () {{SGDpaper|S000149799}} PMID 22687599</ref><ref name='S000114597'>Iwahashi Y, et al. (2006) Mechanisms of patulin toxicity under conditions that inhibit yeast growth. J Agric Food Chem 54(5):1936-42 {{SGDpaper|S000114597}} PMID 16506856</ref><ref name='S000053179'>McHale MW, et al. (1996) Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 gene. Yeast 12(4):319-31 {{SGDpaper|S000053179}} PMID 8701605</ref><ref name='S000127088'>Salin H, et al. (2008) Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics 9:333 {{SGDpaper|S000127088}} PMID 18627600</ref><ref name='S000121157'>de Oliveira IM, et al. (2007) In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. Biochem Biophys Res Commun 355(4):919-25 {{SGDpaper|S000121157}} PMID 17331467</ref><ref name='S000132211'>de Oliveira IM, et al. (2010) The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. Yeast 27(2):89-102 |
| − | {{SGDpaper| | + | {{SGDpaper|S000132211}} PMID 19904831</ref> |
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Latest revision as of 13:05, 5 July 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YCL026C-A |
| Gene name | FRM2 |
| Aliases | YCLX08C |
| Feature type | ORF, Verified |
| Coordinates | Chr III:75285..74704 |
| Primary SGDID | S000000589 |
Description of YCL026C-A: Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin[1][2][3][4][5][6][7]
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References
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- ↑ Azevedo D, et al. (2007) The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain. FEBS Lett 581(2):187-195 SGD PMID 17187783
- ↑ Bang SY, et al. (2012) Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Biochem Biophys Res Commun () SGD PMID 22687599
- ↑ Iwahashi Y, et al. (2006) Mechanisms of patulin toxicity under conditions that inhibit yeast growth. J Agric Food Chem 54(5):1936-42 SGD PMID 16506856
- ↑ McHale MW, et al. (1996) Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 gene. Yeast 12(4):319-31 SGD PMID 8701605
- ↑ Salin H, et al. (2008) Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics 9:333 SGD PMID 18627600
- ↑ de Oliveira IM, et al. (2007) In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. Biochem Biophys Res Commun 355(4):919-25 SGD PMID 17331467
- ↑ de Oliveira IM, et al. (2010) The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. Yeast 27(2):89-102 SGD PMID 19904831
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