Difference between revisions of "YGR155W"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003387 YGR155W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CYS4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CYS4 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
− | |nowrap| Chr VII: | + | |nowrap| Chr VII:798543..800066 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003387 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003387 | ||
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− | '''Description of YGR155W:''' Cystathionine beta-synthase, catalyzes | + | '''Description of YGR155W:''' Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria<ref name='S000148801'>Hoose SA, et al. (2012) A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet 8(3):e1002590 {{SGDpaper|S000148801}} PMID 22438835</ref><ref name='S000052237'>Ono B, et al. (1988) Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency. J Bacteriol 170(12):5883-9 {{SGDpaper|S000052237}} PMID 3056921</ref><ref name='S000042385'>Ono B, et al. (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9 {{SGDpaper|S000042385}} PMID 8017103</ref><ref name='S000062636'>Shan X and Kruger WD (1998) Correction of disease-causing CBS mutations in yeast. Nat Genet 19(1):91-3 {{SGDpaper|S000062636}} PMID 9590298</ref><ref name='S000130695'>Singh S, et al. (2009) Relative Contributions of Cystathionine {beta}-Synthase and {gamma}-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions. J Biol Chem 284(33):22457-66 |
− | {{SGDpaper| | + | {{SGDpaper|S000130695}} PMID 19531479</ref> |
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Latest revision as of 14:05, 26 March 2012
Share your knowledge...Edit this entry! <protect>
Systematic name | YGR155W |
Gene name | CYS4 |
Aliases | NHS5, STR4, VMA41 |
Feature type | ORF, Verified |
Coordinates | Chr VII:798543..800066 |
Primary SGDID | S000003387 |
Description of YGR155W: Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria[1][2][3][4][5]
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References
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- ↑ Hoose SA, et al. (2012) A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet 8(3):e1002590 SGD PMID 22438835
- ↑ Ono B, et al. (1988) Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency. J Bacteriol 170(12):5883-9 SGD PMID 3056921
- ↑ Ono B, et al. (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9 SGD PMID 8017103
- ↑ Shan X and Kruger WD (1998) Correction of disease-causing CBS mutations in yeast. Nat Genet 19(1):91-3 SGD PMID 9590298
- ↑ Singh S, et al. (2009) Relative Contributions of Cystathionine {beta}-Synthase and {gamma}-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions. J Biol Chem 284(33):22457-66 SGD PMID 19531479
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