Difference between revisions of "YOL068C"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005429 YOL068C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HST1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HST1 '' | ||
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− | '''Description of YOL068C:''' NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance<ref name=' | + | '''Description of YOL068C:''' NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance<ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000066205'>Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 {{SGDpaper|S000066205}} PMID 11711434</ref><ref name='S000060164'>Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 {{SGDpaper|S000060164}} PMID 11316790</ref><ref name='S000048730'>Smith JS, et al. (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63 {{SGDpaper|S000048730}} PMID 10841563</ref><ref name='S000060275'>Sutton A, et al. (2001) A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol Cell Biol 21(10):3514-22 {{SGDpaper|S000060275}} PMID 11313477</ref><ref name='S000040525'>Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54 |
− | {{SGDpaper| | + | {{SGDpaper|S000040525}} PMID 10562556</ref> |
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
Systematic name | YOL068C |
Gene name | HST1 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr XV:201879..200368 |
Primary SGDID | S000005429 |
Description of YOL068C: NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance[1][2][3][4][5][6]
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Community Commentary
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Interactions
Physical
Physical interaction with Sum1
Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. [3] [7]
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References
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- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 SGD PMID 11711434
- ↑ 3.0 3.1 Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 SGD PMID 11316790
- ↑ Smith JS, et al. (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63 SGD PMID 10841563
- ↑ Sutton A, et al. (2001) A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol Cell Biol 21(10):3514-22 SGD PMID 11313477
- ↑ Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54 SGD PMID 10562556
- ↑ submitted by Hunter Fraser on 2003-03-14
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