Difference between revisions of "YKL114C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001597 YKL114C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''APN1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''APN1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XI: | + | |nowrap| Chr XI:224455..223352 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001597 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001597 | ||
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| − | '''Description of YKL114C:''' Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine<ref name='S000039558'>Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 {{SGDpaper|S000039558}} PMID 1693433</ref><ref name='S000054159'>Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44 {{SGDpaper|S000054159}} PMID 1715020 | + | '''Description of YKL114C:''' Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine<ref name='S000082522'>Ishchenko AA, et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25(15):6380-90 {{SGDpaper|S000082522}} PMID 16024777</ref><ref name='S000039558'>Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 {{SGDpaper|S000039558}} PMID 1693433</ref><ref name='S000054159'>Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44 |
| − | + | {{SGDpaper|S000054159}} PMID 1715020</ref> | |
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| − | + | The apn1::kanmx4 homozygous diploid mutant from the BY4743 deletion mutant collection displays a growth defect unrelated to the apn1::kanmx4 marker. The haploid BY4742 apn1 deletion mutant also displays this growth defect, suggesting an unidentified semi-dominant mutation arose during construction of this strain. Reconstruction of apn1::kanmx4 in by4741 or by4742 did not recapitulate this growth defect. Literature on the apn1 mutation confirms that apn1 deletion does not normally confer a growth defect in standard (YPD, SD) medium. | |
| + | Colin MacDiarmid, personal communication. | ||
Latest revision as of 11:08, 18 December 2015
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| Systematic name | YKL114C |
| Gene name | APN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:224455..223352 |
| Primary SGDID | S000001597 |
Description of YKL114C: Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine[1][2][3]
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Contents
Community Commentary
About Community Commentary. Please share your knowledge!
The apn1::kanmx4 homozygous diploid mutant from the BY4743 deletion mutant collection displays a growth defect unrelated to the apn1::kanmx4 marker. The haploid BY4742 apn1 deletion mutant also displays this growth defect, suggesting an unidentified semi-dominant mutation arose during construction of this strain. Reconstruction of apn1::kanmx4 in by4741 or by4742 did not recapitulate this growth defect. Literature on the apn1 mutation confirms that apn1 deletion does not normally confer a growth defect in standard (YPD, SD) medium.
Colin MacDiarmid, personal communication.
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References
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- ↑ Ishchenko AA, et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25(15):6380-90 SGD PMID 16024777
- ↑ Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 SGD PMID 1693433
- ↑ Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44 SGD PMID 1715020
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