Difference between revisions of "YML120C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004589 YML120C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004589 YML120C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''NDI1 ''
 
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'''Description of YML120C:''' NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID<ref name='S000123951'>Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 {{SGDpaper|S000123951}} PMID 17761666</ref><ref name='S000114324'>Li W, et al. (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11 {{SGDpaper|S000114324}} PMID 16436509</ref><ref name='S000060343'>Velazquez I and Pardo JP (2001) Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Arch Biochem Biophys 389(1):7-14 {{SGDpaper|S000060343}} PMID 11370674</ref><ref name='S000058452'>Marres CA, et al. (1991) Isolation and inactivation of the nuclear gene encoding the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Eur J Biochem 195(3):857-62
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'''Description of YML120C:''' NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; under stress, N-terminus of Ndi1p is cleaved to be activated within mitochondria and the truncated Ndi1p translocates to cytoplasm to perform apoptosis; homolog of human AMID<ref name='S000151060'>Cui Y, et al. (2012) Mitochondrial Release of the NADH Dehydrogenase Ndi1 Induces Apoptosis in Yeast. Mol Biol Cell () {{SGDpaper|S000151060}} PMID 22993213</ref><ref name='S000114324'>Li W, et al. (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11 {{SGDpaper|S000114324}} PMID 16436509</ref><ref name='S000058452'>Marres CA, et al. (1991) Isolation and inactivation of the nuclear gene encoding the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Eur J Biochem 195(3):857-62 {{SGDpaper|S000058452}} PMID 1900238</ref><ref name='S000123951'>Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 {{SGDpaper|S000123951}} PMID 17761666</ref><ref name='S000060343'>Velazquez I and Pardo JP (2001) Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Arch Biochem Biophys 389(1):7-14
  {{SGDpaper|S000058452}} PMID 1900238</ref>
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  {{SGDpaper|S000060343}} PMID 11370674</ref>
 
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Latest revision as of 13:05, 1 October 2012

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Systematic name YML120C
Gene name NDI1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:29807..28266
Primary SGDID S000004589


Description of YML120C: NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; under stress, N-terminus of Ndi1p is cleaved to be activated within mitochondria and the truncated Ndi1p translocates to cytoplasm to perform apoptosis; homolog of human AMID[1][2][3][4][5]




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References

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  1. Cui Y, et al. (2012) Mitochondrial Release of the NADH Dehydrogenase Ndi1 Induces Apoptosis in Yeast. Mol Biol Cell () SGD PMID 22993213
  2. Li W, et al. (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11 SGD PMID 16436509
  3. Marres CA, et al. (1991) Isolation and inactivation of the nuclear gene encoding the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Eur J Biochem 195(3):857-62 SGD PMID 1900238
  4. Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 SGD PMID 17761666
  5. Velazquez I and Pardo JP (2001) Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Arch Biochem Biophys 389(1):7-14 SGD PMID 11370674

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